Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages

Microbial Pathogenesis
Yuriko OzekiKazuo Kobayashi

Abstract

We aimed to reveal the regulatory function of macrophage scavenger receptor-A (MSR-A) in proinflammatory cytokine production by macrophages stimulated with mycobacterial cord factor (CF). By the culture with CF, MSR-A (+/+) alveolar macrophages and Kupffer cells produced TNF-alpha/MIP-1alpha in a time- and dose-dependent manner. However, the amounts of cytokines produced by them were much less compared to those produced by MSR-A (-/-) macrophages. Consistent with this, treatment of MSR-A (+/+) macrophages with anti-MSR-A antibody increased TNF-alpha production. Binding of CF to MSR-A was demonstrated by measuring the binding affinity. These results indicate that CF binds MSR-A, and MSR-A down-regulates TNF-alpha/MIP-1alpha production by activated macrophages, suggesting the role of this receptor in suppression of excessive inflammatory responses during mycobacterial infection.

References

Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D W DunneK A Joiner
Dec 1, 1996·American Journal of Respiratory Cell and Molecular Biology·S ZimmerliJ D Ernst
Jun 20, 1998·The Journal of Biological Chemistry·K BurnsJ Tschopp
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Trahey, I L Weissman
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M UnderhillA Aderem
Jan 6, 2000·The Journal of Experimental Medicine·C A ThomasJ El Khoury
Aug 21, 2003·Microbial Pathogenesis·Marco Antonio Velasco-VelázquezJosé Agramonte-Hevia
Oct 3, 2003·Biochemical and Biophysical Research Communications·Woojin Scott KimMason W Freeman
Jul 17, 2004·International Journal of Experimental Pathology·Alexander Pedroza-GonzálezLeopoldo Flores-Romo

❮ Previous
Next ❯

Citations

Jul 31, 2009·Pflügers Archiv : European journal of physiology·Ken ShiratoHideki Ohno
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Dec 17, 2009·The Journal of Experimental Medicine·Eri IshikawaSho Yamasaki
Oct 12, 2013·Neurotoxicity Research·P MurgasR von Bernhardi
Apr 25, 2009·Cellular Microbiology·Thomas Areschoug, Siamon Gordon
Apr 25, 2013·Journal of Biomedical Materials Research. Part a·Ryan J Love, Kim S Jones
Feb 18, 2010·European Journal of Immunology·Yunying ChenMikael C I Karlsson
Feb 24, 2015·Immunological Reviews·Chelsea E StammMichael U Shiloh
Jul 13, 2012·Immunobiology·Lisa HeitmannChristoph Hölscher
Sep 23, 2014·Nature Communications·Miyako TanakaYoshihiro Ogawa
May 10, 2017·Infection and Immunity·Judith SchickRoland Lang
Dec 29, 2006·American Journal of Physiology. Cell Physiology·Dejan M NikolicSteven R Post
May 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie CourtValérie F J Quesniaux
Feb 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanne SchoenenRoland Lang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.