Macrophage signaling pathways: a novel target in renal disease

Seminars in Nephrology
Frank Y MaD J Nikolic-Paterson

Abstract

Monocytes/macrophages are a heterogeneous cell population that play a critical role in host defense and tissue homeostasis. However, macrophage activation during acute and chronic inflammation can result in macrophage-mediated renal injury in a variety of settings, including proliferative glomerulonephritis. Macrophages can be activated via a number of intracellular signaling pathways (eg, c-Jun amino terminal kinase, p38 mitogen-activated protein kinase, FcR/Syk, Janus kinase/signal transducer and activator of transcription) that induce production of mediators of renal injury. Thus, targeting selected macrophage signaling pathways is a potential therapeutic strategy to suppress macrophage-mediated renal injury while leaving intact the desirable macrophage functions of host defense and tissue repair.

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Citations

Jun 21, 2014·Seminars in Immunopathology·Carole HéniquePierre-Louis Tharaux
Jan 18, 2013·American Journal of Physiology. Cell Physiology·Gabriela CampanholleJeremy S Duffield
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Jul 14, 2010·Seminars in Nephrology·Steven J ChadbanJeremy Hughes
Jul 14, 2010·Seminars in Nephrology·Madeleine A VernonJeremy Hughes

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