Macrophage stimulating 1-induced inflammation response promotes aortic aneurysm formation through triggering endothelial cells death and activating the NF-κB signaling pathway.

Journal of Receptor and Signal Transduction Research
Kai LuWeili Liu

Abstract

Aortic aneurysm formation is associated with endothelial cells dysfunction through an undefined mechanism. Macrophage stimulating 1 (Mst1) and NF-κB signaling pathway have been found to be related to inflammation response in endothelial cell damage. The goal of our study is to explore the role of Mst1 in regulating endothelial cell viability with a focus on NF-κB signaling pathway and inflammation response. Endothelial cell viability and death were determined via immunofluorescence and ELISA. Agonist of NF-κB signaling pathway and siRNA against Mst1 were used. The results in our study demonstrated that Mst1 transcription and expression were significantly elevated after exposure to oxidative stress in endothelial cells. Once loss of Mst1 through transfection of siRNA (si-Mst1), endothelial cell viability and survival rate were rapidly increased in response to oxidative stress. In addition, we also found that Mst1 controlled inflammation response and mitochondrial function in endothelial cells. Re-activation of NF-κB signaling pathway was followed by an activation of inflammation response and mitochondrial dysfunction, as evidenced by increased expression of inflammation factors and decreased ATP synthesis. Altogether, our result...Continue Reading

References

Oct 11, 2017·Angiogenesis·Christina KörbelMatthias W Laschke
Mar 9, 2018·Angiogenesis·Tatyana Merkulova-RainonBernard I Lévy
Apr 9, 2018·Angiogenesis·Edward DanielOndine Cleaver
May 17, 2018·Angiogenesis·Patrycja Nowak-SliwinskaArjan W Griffioen
Jun 28, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael F Bode, Ingo Hilgendorf
Sep 2, 2018·Angiogenesis·V van DuinenT Hankemeier
Jan 24, 2019·Basic Research in Cardiology·Lisa KraftKarin Klingel
Feb 2, 2019·Cell Biology and Toxicology·Jing LiMing Liu
Jun 5, 2019·Pharmaceutical Research·Tomasz JelińskiPiotr Cysewski

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