Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration

American Journal of Respiratory Cell and Molecular Biology
C G WillettM E Sunday

Abstract

Previously, we identified macrophage-stimulating protein (MSP) as being expressed during hamster lung injury induced by nitrosamine carcinogens. Transient, generalized epithelial-cell hyperplasia during the preneoplastic period, and eventually nonneuroendocrine (non-NE) lung tumors, are known to develop in these nitrosamine-treated hamsters. We wished to test the hypothesis that MSP and its tyrosine kinase receptor, RON, might represent an autocrine/paracrine system involved in the pathogenesis of human nonneuroendocrine lung tumors, the non-small-cell carcinomas (NSCLCs). We found that this occurred in a paracrine fashion in three of eight primary human NSCLCs that expressed messenger RNA (mRNA) for MSP at high levels in histologically normal lung adjacent to the tumor, but not in the primary tumor, together with mRNA for RON in both normal and tumor tissue. MSP and RON could also constitute an autocrine/paracrine system in human NSCLC cell lines: five of 16 cell lines (squamous and adenosquamous) expressed both MSP and RON; and an additional five of 16 cell lines expressed RON without detectable MSP. Although three cases of primary squamous-cell carcinomas expressed MSP (two of three in the tumor and one of three in nonneopla...Continue Reading

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Citations

Jun 6, 2003·Molecular and Cellular Probes·Debora AngeloniMichael I Lerman
May 22, 2001·Molecular Biology of the Cell·M C StellaP M Comoglio
May 27, 2003·The American Journal of Surgical Pathology·Teresa RampinoAntonio Dal Canton
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Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Teresa RampinoAntonio Dal Canton

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