PMID: 6977550Jan 1, 1981Paper

Macrophage T-cell interaction in man: handling of tetanus toxoid antigen by human monocytes

Journal of Clinical Immunology
S D AlpertR S Geha

Abstract

An absolute requirement for monocytes was demonstrated in the T-cell proliferative response to tetanus toxoid (TT) antigen. Antigen-pulsed monocytes were shown to be effective in triggering T-cell proliferation. Using 125I-radiolabeled TT antigen, uptake by monocytes increased progressively over an 18-hr period, at which time 80-85% of the monocytes contained radiolabeled material. The ability of antigen-pulsed monocytes to trigger T-cell proliferation paralleled antigen uptake over an 18-hr period. Monocytes pulsed with antigen, then washed, lost their ability to trigger T-cell proliferation following a 24- to 48-hr culture period. Metabolic inhibitors blocked antigen uptake by monocytes and monocyte triggering of T-cell proliferation. Trypsin treatment of TT-pulsed monocytes did not affect the amount of antigen associated with monocytes or T-cell triggering by monocytes. Anti HLA-DR alloantibodies, which when added during antigen pulsing of monocytes inhibit the capacity of these monocytes to trigger T-cell proliferation, did not interfere with antigen uptake. These results indicate that human monocytes present antigen to T cells via an active process and in association with Dr determinants, and that the immunogenic moiety of...Continue Reading

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R S GehaE J Yunis
Jan 1, 1978·Immunological Reviews·E R Unanue
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G M EdelmanJ L Wang
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Apr 1, 1970·The Journal of Experimental Medicine·E R Unanue, J C Cerottini
Nov 1, 1970·Immunochemistry·S Sonoda, M Schlamowitz

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Citations

Jan 1, 1987·International Journal of Immunopharmacology·A H EsaA D Hess
Dec 1, 1986·Human Immunology·T L GerrardA S Fauci
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E T ChuR S Geha
Jul 1, 1983·The Journal of Experimental Medicine·W C Van VoorhisR M Steinman
Sep 1, 1984·The Journal of Clinical Investigation·T A Gonwa, J D Stobo
Aug 1, 1984·Scandinavian Journal of Immunology·R VuentoA Toivanen

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