Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.

The Journal of Biological Chemistry
Yuka KobayashiShiroh Kishioka

Abstract

Peripheral neuroinflammation caused by activated immune cells can provoke neuropathic pain. Herein, we investigate the actions of macrophages and T cells through glucocorticoid-induced tumor neurosis factor receptor ligand (GITRL) and its receptor (GITR) in neuropathic pain. After partial sciatic nerve ligation (PSL) in enhanced green fluorescent protein (eGFP) chimeric mice generated by the transplantation of eGFP(+) bone marrow cells, eGFP(+) macrophages, and T cells markedly migrated to the injured site after PSL. Administration of agents to deplete macrophages (liposome-clodronate and Clophosome-A(TM)) or T cells (anti-CD4 antibody and FTY720) could suppress PSL-induced thermal hyperalgesia and tactile allodynia. The expression levels of co-stimulatory molecules GITRL and GITR were increased on infiltrating macrophages and T cells, respectively. The perineural injection of a GITRL neutralizing antibody that could inhibit the function of the GITRL-GITR pathway attenuated PSL-induced neuropathic pain. Additionally, the induction of inflammatory cytokines and the accumulation of GITR(+) T cells in the injured SCN were abrogated after macrophage depletion by Clophosome-A(TM). In conclusion, GITRL expressed on macrophages drives...Continue Reading

References

Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Apr 9, 1993·Cell·T Taniguchi, Y Minami
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·G NocentiniC Riccardi
Apr 23, 2002·The Journal of Biological Chemistry·Volker BrinkmannKevin R Lynch
Jul 5, 2005·Nature Reviews. Neuroscience·Fabien MarchandStephen B McMahon
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Salvatore CuzzocreaCarlo Riccardi
Jul 27, 2006·Nature Reviews. Immunology·Ethan M Shevach, Geoffrey L Stephens
Aug 26, 2006·Nature Clinical Practice. Neurology·Ralf Baron
Oct 4, 2006·Neuron·James N Campbell, Richard A Meyer
Aug 25, 2007·Anesthesia and Analgesia·Michael A ThackerStephen B McMahon
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
May 23, 2008·Journal of Cellular and Molecular Medicine·Ovidiu CosteKlaus Scholich
Feb 12, 2010·Annals of the New York Academy of Sciences·Scott M Steward-TharpJohn J O'Shea
Jun 7, 2011·The American Journal of Pathology·Yuka OkadaShizuya Saika
Aug 16, 2011·Current Opinion in Immunology·Bruce M HallSuzanne J Hodgkinson
Oct 25, 2011·Current Opinion in Pharmacology·Norikazu KiguchiShiroh Kishioka
Apr 17, 2012·Biochemical and Biophysical Research Communications·Yuka KobayashiShiroh Kishioka
Jun 20, 2012·Lancet Neurology·Margarita CalvoDavid L H Bennett
Oct 11, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gongxian LiaoCox Terhorst

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Citations

Oct 30, 2016·Trends in Immunology·Felipe A Pinho-RibeiroIsaac M Chiu
Nov 7, 2017·International Journal of Molecular Sciences·Norikazu KiguchiShiroh Kishioka
Mar 24, 2018·Anesthesia and Analgesia·Tomofumi MiuraAtsushi Ochiai
Jul 26, 2017·Molecular Pain·Stacie K Totsch, Robert Ernest Sorge
Jan 4, 2019·The Journal of Pharmacology and Experimental Therapeutics·Fumihiro SaikaShiroh Kishioka
Oct 3, 2017·Rheumatology·Ramin RaoofNiels Eijkelkamp
Oct 2, 2019·Frontiers in Molecular Neuroscience·Geoffroy LaumetAnnemieke Kavelaars
Nov 19, 2019·The Journal of Veterinary Medical Science·Shuhei TakadaRyushin Mizuta
Jan 22, 2020·BMC Musculoskeletal Disorders·Nobuhiro ShimadaSatoshi Nishimura
Aug 19, 2020·The Journal of Headache and Pain·Binbin LinGang Chen
Nov 5, 2019·Frontiers in Pharmacology·Tabea Osthues, Marco Sisignano
Feb 15, 2020·International Journal of Molecular Sciences·Giuseppe BanfiEva Reali
Sep 26, 2020·Frontiers in Physiology·Hana StarobovaIrina Vetter
Feb 17, 2017·Journal of Translational Medicine·Kely Campos NavegantesMarta Chagas Monteiro
Feb 10, 2021·International Journal of Molecular Sciences·Petra BaumJoanna Kosacka
Feb 5, 2021·International Journal of Molecular Sciences·Jessica Aijia LiuChi Wai Cheung
May 4, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Débora da Luz Scheffer, Alexandra Latini
Mar 31, 2021·Rheumatic Diseases Clinics of North America·Ejaz M I Pathan, Robert D Inman
Jun 22, 2021·International Reviews of Immunology·Kevin M HarrisLinda R Watkins
Jul 17, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Valentina MalafogliaAntonello Bonci
Aug 17, 2021·Journal of Oral Rehabilitation·Lu GaoHaiwei Jin
Nov 19, 2021·Purinergic Signalling·Manuel F MuñozJorge E Contreras

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