PMID: 8971004Dec 1, 1996Paper

Macrophages and CD4+ T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1

Journal of Virology
R I ConnorR A Koup

Abstract

Despite multiple, high-risk sexual exposures, some individuals remain uninfected with human immunodeficiency virus type 1 (HIV-1). CD4+ lymphocytes from these individuals are less susceptible to infection in vitro with some strains of HIV-1, suggesting that the phenotype of the virus may influence its ability to interact with certain CD4+ cells. In the present study, we examined the susceptibility of CD4+ T lymphocytes and macrophages from two exposed uninfected individuals (EU2 and EU3) to infection with a panel of biologically cloned isolates of HIV-1 having either a non-syncytium-inducing (NSI) or a syncytium-inducing (SI) phenotype. Our results indicate that CD4+ T lymphocytes from EU2 and EU3 are resistant to infection with NSI isolates of HIV-1 but are susceptible to infection with primary SI isolates. In addition, we found that macrophages from EU2 and EU3 are resistant to infection with both NSI and SI isolates. The latter finding was confirmed by using several uncloned NSI and SI isolates obtained from patients during acute HIV-1 infection. In further experiments, env clones encoding glycoproteins characteristic of NSI or SI viruses were used in single-cycle infectivity assays to evaluate infection of CD4+ lymphocytes ...Continue Reading

References

Mar 1, 1992·The Journal of Infectious Diseases·M T RoosM Tersmette
Jul 11, 1986·Science·S GartnerM Popovic
Dec 15, 1995·The Journal of Biological Chemistry·C CombadiereP M Murphy
Jan 20, 1996·AIDS Research and Human Retroviruses·D BhattacharyyaL Callahan

❮ Previous
Next ❯

Citations

Feb 17, 1997·The Journal of Experimental Medicine·R I ConnorN R Landau
Nov 14, 1997·AIDS Research and Human Retroviruses·L ZhangD D Ho
Jan 1, 1997·Springer Seminars in Immunopathology·W A Paxton, R A Koup
Nov 19, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Tonie Cilliers, Lynn Morris
Aug 13, 1999·AIDS Research and Human Retroviruses·S HibbittsP R Clapham
Feb 6, 1997·Nature·M T DittmarP Simmonds
Dec 16, 2005·Cell Research·Tuo Fu ZhuBo Ping Zhou
Jun 8, 1999·Annual Review of Immunology·E A BergerJ M Farber
Feb 14, 1998·AIDS Research and Human Retroviruses·P Di MarzioN R Landau
Apr 9, 2010·Retrovirology·Anna Bergamaschi, Gianfranco Pancino
May 22, 2019·Expert Opinion on Drug Delivery·Mrunal JadhavAbdelwahab Omri
Jan 9, 1999·Journal of Virology·J T KimataJ Overbaugh
Aug 17, 1999·Current Opinion in Immunology·N L Michael

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.