Macrophages and T-cell apoptosis in HIV infection: a leading role for accessory cells?

Trends in Immunology
U Mahlknecht, Georges Herbein

Abstract

Recent studies indicate that macrophages modulate T-cell apoptosis in HIV infection. Macrophages have been shown to trigger apoptosis of uninfected bystander T cells and to protect HIV-infected T cells from apoptosis. This article raises the possibility that macrophages, via modulation of T-cell apoptosis, play a crucial role in both immune suppression and the formation of viral reservoirs during HIV infection.

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Citations

Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·E De GregorioB Lemaitre
Apr 12, 2003·AIDS Research and Human Retroviruses·Jean-Charles GrivelLeonid B Margolis
Apr 13, 2010·Retrovirology·Georges Herbein, Audrey Varin
Apr 13, 2010·Retrovirology·Georges HerbeinWasim Abbas
Jun 16, 2010·Retrovirology·Rafael Van den BerghGeert Raes
Jan 8, 2008·Trends in Immunology·Georges Herbein, Kashif Aziz Khan
Oct 19, 2004·Molecular Immunology·Alessia VeraniGianfranco Pancino
Dec 27, 2005·The Lancet Infectious Diseases·Rafael Van den BerghRobert Colebunders
Oct 31, 2012·Journal of Theoretical Biology·Denis Fils Nkoa OnanaDjomangan Adama Ouattara
Apr 9, 2005·Cell Death and Differentiation·B HurtrelJ Estaquier
Nov 10, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mansi SaxenaAshok Kumar
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Apr 14, 2018·Viruses·Sébastien PasquereauGeorges Herbein
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annie DavidGianfranco Pancino

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis