PMID: 11323283DOI: 10.1016/s1471-4906(01)01898-1Apr 27, 2001Paper
Macrophages and T-cell apoptosis in HIV infection: a leading role for accessory cells?
Trends in Immunology
U Mahlknecht, Georges Herbein
Abstract
Recent studies indicate that macrophages modulate T-cell apoptosis in HIV infection. Macrophages have been shown to trigger apoptosis of uninfected bystander T cells and to protect HIV-infected T cells from apoptosis. This article raises the possibility that macrophages, via modulation of T-cell apoptosis, play a crucial role in both immune suppression and the formation of viral reservoirs during HIV infection.
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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis
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