Macrophages Are Phenotypically and Functionally Diverse across Tissues in Simian Immunodeficiency Virus-Infected and Uninfected Asian Macaques

Journal of Virology
A OrtizJason M Brenchley

Abstract

Macrophages regulate tissue immunity, orchestrating the initiation and resolution of antimicrobial immune responses and repair of damaged tissue architecture. Their dysfunction can, thus, manifest in either pro- and anti-inflammatory responses. Indeed, despite the importance of macrophage function in health and disease, the role of tissue-resident macrophages in human immunodeficiency virus (HIV) disease progression remains incompletely defined. Here, we use flow cytometry to assess the phenotypes and functions of macrophages isolated from the spleens, axillary lymph nodes, colons, jejuna, and livers of healthy and chronically simian immunodeficiency virus (SIV)-infected Asian macaques, the prominent nonhuman primate model for HIV infection. Our data demonstrate that macrophages from healthy animals exhibit considerable phenotypic and functional heterogeneity across tissues and across a variety of stimuli. Further, our analysis reveals changes in the lipopolysaccharide (LPS) responsiveness of macrophages isolated from SIV-infected animals. We anticipate that our findings will inform future research into macrophage-directed immunity across a variety of primate diseases. These findings highlight the functional and phenotypic hete...Continue Reading

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Citations

Nov 10, 2015·European Journal of Immunology·Zachary D SwanSimon M Barratt-Boyes
Aug 6, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Sueli Akemi TaniwakiJoão Pessoa Araujo
Oct 14, 2017·Current Opinion in HIV and AIDS·Alexandra M Ortiz, Jason M Brenchley
Mar 31, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naofumi TakahashiMarcelo J Kuroda
Jul 10, 2019·Journal of Leukocyte Biology·Daniel I PetkovMarcelo J Kuroda
Sep 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammad Arif RahmanMarjorie Robert-Guroff
Aug 25, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth R WonderlichSimon M Barratt-Boyes
Jun 17, 2016·Journal of Virology·Sarah R DiNapoliJason M Brenchley
Sep 30, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristin LadellJoseph M McCune

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