PMID: 8611471Apr 1, 1996Paper

Macrophages are the major target cell for HIV infection in long-term marrow culture and demonstrate dual susceptibility to lymphocytotropic and monocytotropic strains of HIV-1

British Journal of Haematology
V GillF M Gibson

Abstract

Haematological abnormalities are often seen in patients infected with HIV. A number of mechanisms are thought to contribute to this bone marrow suppression, including impaired stromal function and direct infection of progenitor cells. Evidence suggests that both bone marrow progenitor cells and perhaps stromal cells are open to infection by HIV, which raises the possibility that bone marrow stromal cells may serve as a reservoir for HIV. This study investigated the cellular targets and kinetics of in vitro infection of stroma in long-term bone marrow culture (LTBMC) using both mono- and lymphocytotropic strains of HIV-1. p24 ELISA and reverse transcriptase (RT) assay demonstrated that stroma could be infected with HIV and release infectious virions. The target cells for infection were shown to be macrophages by immunohistochemistry (APAAP), dual immunofluorescence staining (using CD68 and p24) and electron microscopy. The data show that it was possible to infect stroma in LTBMC with HIV and that such infection was productive. The main target for infection was bone marrow macrophages. In contrast to peripheral blood derived macrophages, these cells were susceptible to both lymphocytotropic and monocytotropic strains of HIV-1. Th...Continue Reading

Citations

Oct 11, 2005·Autoimmunity Reviews·Antonella IsgròFernando Aiuti
Sep 29, 2006·The New England Journal of Medicine·David T ScaddenRobert P Hasserjian
Oct 24, 2000·Leukemia & Lymphoma·J KulkoskyR J Pomerantz
Mar 25, 2014·International Reviews of Immunology·Xin ShiPing Zhang
Apr 13, 2000·Clinical and Laboratory Haematology·A DaviesJ Webster-King
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Chang I LeeAlice F Tarantal
Mar 6, 2019·Current HIV/AIDS Reports·Brooks I MitchellLishomwa C Ndhlovu
Oct 6, 2017·Archives of Virology·Mahmoud Mohammad YaseenBarakat Mohammad Shabsoug

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