Macrophages, but not dendritic cells, present collagen to T cells

European Journal of Immunology
E MichaëlssonR Holmdahl

Abstract

Dendritic cells, such as epidermal Langerhans cells, play a crucial role for the antigen-specific priming of T cells. We have addressed the question whether dendritic cells present collagen, a major protein component in tissues through which dendritic cells migrate, i.e. the basement membrane, dermis, and synovial tissue. Langerhans cells, spleen cells and peritoneal macrophages were compared for antigen-presenting capacity using a panel of mouse T cell hybridomas reactive with different determinants on type II collagen, myelin basic protein, ovalbumin and pepsin. Langerhans cells did not present any of the type II collagen determinants, unless the antigen was administered as a 15-mer peptide, but did present myelin basic protein, ovalbumin and pepsin. Spleen cells and peritoneal macrophages, in contrast, presented all type II collagen determinants. This biased antigen presentation was also observed when Langerhans cells were pulsed with antigen in vivo. The inability to present type II collagen is related to the collagen sequence as such, since both native type II collagen, type II collagen alpha chains, as well as a type II collagen determinant incorporated in type I collagen, were not presented by Langerhans cells. In additi...Continue Reading

References

Jul 14, 1977·Nature·S Gillis, K A Smith
Jun 23, 1977·Nature·R A GoldsbyL A Herzenberg
Nov 13, 1992·Science·E J Fuchs, P Matzinger
May 1, 1992·The Journal of Experimental Medicine·K InabaG Schuler
Jun 11, 1991·The Journal of Experimental Medicine·R H LinC A Janeway
Oct 1, 1990·The Journal of Investigative Dermatology·S L TiegsD Rowley
Nov 1, 1990·The Journal of Experimental Medicine·C P LarsenJ M Austyn
Jun 1, 1986·The Journal of General Virology·P H van der MeideH Schellekens
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M LondeiM Feldmann
Jun 30, 1989·Cell·R H Schwartz
Oct 1, 1989·The Journal of Experimental Medicine·R BujdosoI McConnell
Jun 1, 1982·The Journal of Investigative Dermatology·A ScheyniusC Sundström
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L KlareskogH Wigzell
Jul 1, 1994·European Journal of Immunology·U BrunsbergR Holmdahl
Aug 1, 1994·The Journal of Experimental Medicine·E MichaëlssonR Holmdahl
Aug 1, 1993·The Journal of Experimental Medicine·C Reis e SousaJ M Austyn

❮ Previous
Next ❯

Citations

Jun 1, 2002·Ageing Research Reviews·Rikard HolmdahlHisakata Yamada
May 1, 1997·Human Immunology·S C Schneider, E E Sercarz
Jun 1, 1997·Immunology and Cell Biology·K Ni, H C O'Neill
Sep 5, 2001·Clinical and Experimental Immunology·B CatchpoleA S Hamblin
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·V MalmströmR Holmdahl
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·John F Seymour
Oct 9, 2012·Annals of the Rheumatic Diseases·Johan BäcklundRikard Holmdahl
Jun 1, 1997·Annals of the Rheumatic Diseases·I K CampbellJ A Hamilton
Jun 23, 2000·The Journal of Clinical Investigation·I K CampbellI P Wicks
Sep 14, 2007·Arthritis Research & Therapy·Viviana LutzkyRanjeny Thomas
Jan 8, 2008·Arthritis Research & Therapy·Raimund W KinneGerd-R Burmester
Nov 30, 2000·Arthritis Research·R W KinneG R Burmester
Jan 5, 2010·Journal of Ethnopharmacology·Tao YuJae Youl Cho
Jul 3, 2007·Journal of Ethnopharmacology·Yong Gyu LeeJae Youl Cho
Apr 10, 2007·Journal of Ethnopharmacology·Yong Gyu LeeJae Youl Cho
Dec 18, 2003·Annals of the New York Academy of Sciences·Helena ReijonenGerald T Nepom
Aug 16, 2011·The American Journal of Pathology·Katja DenningerTord Labuda
Aug 19, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Han Gyung KimJae Youl Cho
Nov 28, 2012·Journal of Ethnopharmacology·Yanyan YangJae Youl Cho
Dec 21, 2011·Journal of Ethnopharmacology·Yanyan YangJae Youl Cho
Apr 5, 1997·Annals of the New York Academy of Sciences·S L Peng, J Craft
Apr 5, 1997·Annals of the New York Academy of Sciences·R HolmdahlM Vestberg
Feb 1, 2006·Arthritis and Rheumatism·Alexei von DelwigJohn H Robinson
Aug 24, 2017·The American Journal of Chinese Medicine·Woo Seok YangJae Youl Cho
Apr 23, 2002·Scandinavian Journal of Immunology·M HolmdahlR Holmdahl
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eleanor C TsarkSusan Kovats

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.