PMID: 8592089Jan 1, 1996Paper

Macrophages, but not Langerhans cell-like cells of dendritic lineage, express the CD36 molecule in normal human dermis: relevance to downregulatory cutaneous immune responses?

The Journal of Investigative Dermatology
A LonatiG De Panfilis

Abstract

The CD36 molecule has been shown to be associated with subsets of peripheral blood monocyte/macrophages and, in cells isolated from either ultraviolet (UV)-irradiated or diseased skin, to induce downregulatory immune responses. Although macrophages are certainly present within normal human dermis, whether they normally express CD36 is still a matter of debate. In this study, we investigated dermal CD36-expressing macrophages in situ using the gold immunoelectron microscopic technique on tissue ultracryosections. This is a very sensitive and specific method, and its results clearly reflect the in vivo immunophenotypic constitutive situation. Macrophages in normal human dermis were variously shaped from round to dendritic and were localized either immediately beneath the epidermis, in perivascular areas, or in intervascular zones. Macrophages showed consistent gold-positive staining on their cell surface. In contrast, other dermal cells, including fibroblasts, lymphocytes, and mast cells, as well as dermal fibers, were not decorated with gold; dermal Langerhans cell-like dendritic cells (LC/DC), though they did show gold labeling in some intracytoplasmic organelles, did not show any gold particles along their plasma membranes. Th...Continue Reading

Citations

Oct 1, 1996·The British Journal of Dermatology·G de Panfilis
Jan 8, 2009·Contact Dermatitis·Mascha J ToebakThomas Rustemeyer
Mar 28, 2013·Mediators of Inflammation·Sadaf Kasraie, Thomas Werfel
Apr 25, 2019·International Journal of Molecular Sciences·Alan V Nguyen, Athena M Soulika
Dec 12, 2001·International Journal of Dermatology·J Abulafia, R A Vignale
Aug 17, 2021·Frontiers in Immunology·Juan Rodriguez-CoiraDomingo Barber

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