DOI: 10.1101/493494Jan 3, 2019Paper

Macrophages enforce the blood nerve barrier

BioRxiv : the Preprint Server for Biology
Liza MalongAlison C Lloyd

Abstract

The specialised blood barriers of the nervous system are important for protecting the neural environment but can hinder therapeutic accessibility. Studies in the central nervous system (CNS) have shown the importance of the cellular components of the neuro-vascular unit for blood-brain barrier (BBB) function. Whilst the endothelial cells (ECs) confer barrier function with specialised tight junctions (TJs) and low levels of transcytosis, pericytes and astrocytes provide complete coverage of the ECs and both deliver essential signals for the development and maintenance of the BBB. In contrast, the blood-nerve barrier (BNB) of the peripheral nervous system (PNS) remains poorly defined. Here, we show that the vascular unit in the PNS has a distinct cellular composition with only partial coverage of the BNB-forming ECs. Using a mouse model, in which barrier function can be controlled, we show the BNB, while less tight than the BBB, is maintained by low levels of transcytosis and the TJs of the ECs, with opening of the barrier associated with increased transcytosis. Importantly, we find that while ECs of the PNS have higher transcytosis rates than those of the CNS, the barrier is reinforced by resident macrophages that specifically e...Continue Reading

Related Concepts

Astrocytes
Blood Vessel
Macrophage
Peripheral Neuropathy
Peripheral
Endothelial Cells
Tight Junctions
Kit, Cell Harvasting, Endothelial
Transcytosis
Pericytes

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