Macrophages in resistance to candidiasis.

Microbiology and Molecular Biology Reviews : MMBR
A Vazquez-Torres, E Balish

Abstract

Candida albicans, an increasingly common opportunistic pathogenic fungus, frequently causes disease in immunodeficient but not immunocompetent hosts. Clarifying the role of the phagocytic cells that participate in resistance to candidiasis not only is basic to understanding how the host copes with this dimorphic pathogen but also will expedite the development of innovative prophylactic and therapeutic approaches for treating the multiple clinical presentations that candidiasis encompasses. In this review, we present evidence that a diverse population of mononuclear phagocytes, in different states of activation and differentiation and from a variety of host species, can phagocytize C. albicans blastoconidia via an array of opsonic and nonopsonic mechanisms and can kill C. albicans blastoconidia and hyphae by means of oxygen-dependent and -independent mechanisms. Reactive nitrogen intermediates should now be added to the well-established candidacidal reactive oxygen intermediates of macrophages. Furthermore, what were thought to be two independent pathways, i.e., nitric oxide and superoxide anion, have now been shown to combine to form a potent macrophage candidacidal molecule, peroxynitrite. In contrast to monocytes and neutroph...Continue Reading

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Citations

Jun 11, 2004·Eukaryotic Cell·Breanna D UllmannMichael C Gustin
Aug 23, 2003·Infection and Immunity·Kieren A MarrW Conrad Liles
Aug 4, 2010·Molecular and Cellular Biology·Alessandra da Silva DantasJanet Quinn
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Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Subhrajit BiswasAsis Datta
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Oct 12, 2011·Antimicrobial Agents and Chemotherapy·Keunsook K LeeCarol A Munro
Sep 8, 2021·Infection and Immunity·Liam F FitzsimmonsTed Hackstadt

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