PMID: 7517644Jun 1, 1994Paper

Macrophages, monocyte chemoattractant peptide-1, and TGF-beta 1 in experimental hydronephrosis

The American Journal of Physiology
J R DiamondN C Restrepo

Abstract

Early cellular and molecular derangements have been evaluated as potential pivotal factors for the late development of interstitial fibrosis after experimental hydronephrosis. In this study, we delineated the kinetics of renal cortical macrophage infiltration as well as the cortical expression of transforming growth factor-beta 1 (TGF-beta 1) and monocyte chemoattractant peptide-1 (MCP-1) at 12, 48, and 96 h after unilateral ureteral obstruction (UUO). Interstitial macrophage number in the obstructed kidney versus the contralateral unobstructed kidney (CUK) significantly increased by 12 (11.1 +/- 0.9 vs. 4.5 +/- 0.6), 48 (27.5 +/- 0.9 vs. 4.0 +/- 0.8), and 96 h (71.4 +/- 4.6 vs. 3.2 +/- 0.4) after UUO. MCP-1 mRNA was detected from 12 to 96 h in the obstructed kidney but was absent in the CUK specimens at all time points. Apical tubular MCP-1 expression, on immunolabeling, was present from 12 through 96 h after UUO in the obstructed kidney but not the CUK specimen. On Northern analysis, there were highly significant 2.6-, 5.8-, and 7.0-fold increments in renal cortical TGF-beta 1 mRNA levels at 12, 48, and 96 h, respectively, in the obstructed kidney versus the CUK specimen. Intracellular TGF-beta 1, on immunolabeling, was detec...Continue Reading

Citations

Jul 15, 2000·American Journal of Physiology. Renal Physiology·K A HruskaJ Morrissey
Aug 15, 2001·American Journal of Physiology. Renal Physiology·K FukudaH Hirakata
Oct 23, 2003·American Journal of Physiology. Renal Physiology·John KanellisDavid Sheikh-Hamad
Dec 13, 2005·American Journal of Physiology. Renal Physiology·Neil G DochertyR William G Watson
May 23, 2008·Journal of the American Society of Nephrology : JASN·Jeong-Hae KieNathalie Hill-Kapturczak
Mar 23, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K AbeS Kohno
Apr 9, 2001·American Journal of Physiology. Renal Physiology·G GuoS Klahr
Dec 16, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K K MeldrumD R Meldrum
Jun 13, 2019·BioFactors·Chandra S PeddakkulappagariChandraiah Godugu
Mar 11, 2000·American Journal of Physiology. Renal Physiology·R F HustedJ B Stokes
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Arup ChakrabortyDavid Sheikh-Hamad
Jan 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Grant BledsoeJulie Chao
May 6, 2004·American Journal of Physiology. Renal Physiology·Ann Wamsley-DavisDavid Sheikh-Hamad
Nov 13, 2003·American Journal of Physiology. Renal Physiology·Joshua M SternDiane Felsen
Jun 15, 2007·American Journal of Physiology. Renal Physiology·Amie TraylorNathalie Hill-Kapturczak
Apr 6, 2002·American Journal of Physiology. Renal Physiology·Hideki YokoiKazuwa Nakao
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Gunter WolfRolf A K Stahl
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Minoru SatohHirofumi Makino
Oct 28, 2021·Drug and Chemical Toxicology·Ismail Necati HakyemezEren Altun

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