Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase

The Journal of Immunology : Official Journal of the American Association of Immunologists
Mahesh YadavJeffrey S Schorey

Abstract

Previous studies have shown that the ability of Mycobacterium tuberculosis to block a Ca(2+) flux is an important step in its capacity to halt phagosome maturation. This affect on Ca(2+) release results from M. tuberculosis inhibition of sphingosine kinase (SPK) activity. However, these studies did not address the potential role of SPK and Ca(2+) in other aspects of macrophage activation including production of proinflammatory mediators. We previously showed that nonpathogenic Mycobacterium smegmatis and to a lesser extent pathogenic Mycobacterium avium, activate Ca(2+)-dependent calmodulin/calmodulin kinase and MAPK pathways in murine macrophages leading to TNF-alpha production. However, whether SPK functions in promoting MAPK activation upon mycobacterial infection was not defined in these studies. In the present work we found that SPK is required for ERK1/2 activation in murine macrophages infected with either M. avium or M. smegmatis. Phosphoinositide-specific phospholipase C (PI-PLC) and conventional protein kinase C (cPKC) were also important for ERK1/2 activation. Moreover, there was increased activation of cPKC and PI3K in macrophages infected with M. smegmatis compared with M. avium. This cPKC and PI3K activation was d...Continue Reading

References

Oct 1, 1993·European Journal of Biochemistry·A Huwiler, J Pfeilschifter
Apr 1, 1996·Current Opinion in Cell Biology·S Jaken
Jun 10, 1998·The EMBO Journal·D Meyer zu HeringdorfC J van Koppen
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·P XiaM A Vadas
Jun 8, 1999·Annual Review of Immunology·A Aderem, D M Underhill
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E C LarsenM R Lennartz
Oct 12, 2000·Biochemical and Biophysical Research Communications·A Breton, A Descoteaux
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Giroux, A Descoteaux
Dec 15, 2000·Annals of the Rheumatic Diseases·J W Bijlsma
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N ReilingS Ehlers
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hubert M TseAndrea M Cooper
May 16, 2002·The Journal of Biological Chemistry·Sarah Spiegel, Sheldon Milstien
Jun 19, 2002·Biochimica Et Biophysica Acta·Michael J Kluk, Timothy Hla
Oct 3, 2002·Journal of Biochemistry·Shigeo Ohno, Yasutomi Nishizuka
Dec 25, 2002·The Journal of Cell Biology·Elaine C LarsenMichelle R Lennartz
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zulfiqar A MalikDavid J Kusner
May 3, 2003·Nature Reviews. Molecular Cell Biology·Carrie M Rosenberger, B Brett Finlay
May 15, 2003·The Journal of Biological Chemistry·Kiyoshi Itagaki, Carl J Hauser
May 31, 2003·Oncogene·Weicheng WuDaniel Broek
Jul 18, 2003·American Journal of Physiology. Cell Physiology·Mònica ComaladaAntonio Celada
Aug 20, 2003·The Journal of Experimental Medicine·Isabelle VergneVojo Deretic
Jan 27, 2004·American Journal of Respiratory Cell and Molecular Biology·Martha M MonickGary W Hunninghake
Mar 24, 2004·Current Opinion in Microbiology·Jennifer ChuaVojo Deretic
Apr 15, 2004·Nature Reviews. Microbiology·Anil KoulAxel Ullrich
Jun 9, 2004·Biochemical and Biophysical Research Communications·John Derek Ng Yan HingAlbert Descoteaux
Jul 20, 2004·Journal of Cellular Biochemistry·Dagmar Meyer Zu Heringdorf
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alirio J Melendez, Farazeela Bte Mohd Ibrahim
Aug 18, 2004·Molecular and Cellular Biology·Weicheng WuDaniel Broek
Aug 24, 2004·Infection and Immunity·Mariela SeguraMartin Olivier
Feb 22, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·David J Kusner

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Citations

Apr 5, 2008·Journal of Lipid Research·Deborah A Lebman, Sarah Spiegel
Apr 4, 2012·Annals of Surgery·Qiurong LiJieshou Li
Apr 1, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rong JiSteven G Kelsen
Oct 15, 2018·Journal of Cellular Biochemistry·Ruchi ParohaRashmi Chourasia
Apr 29, 2008·American Journal of Respiratory Cell and Molecular Biology·Elizabeth P SampaioSteven M Holland
Oct 24, 2007·Immunology·Maria MagocsiJudith Szelenyi
Mar 3, 2010·Infection and Immunity·Travis McQuistonMaurizio Del Poeta
Mar 20, 2010·The Journal of Biological Chemistry·Anke DiAsrar B Malik
Aug 18, 2018·Molecular Neurobiology·Bruno Lima GiacobboErik F J de Vries
Aug 21, 2020·Microbiology and Immunology·Ruchi ParohaAnirudh K Singh
Mar 30, 2021·Frontiers in Cellular and Infection Microbiology·Thiago Souza OnofreNobuko Yoshida
Nov 6, 2010·Cytokine & Growth Factor Reviews·Pu Xia, Carol Wadham
Jul 30, 2011·Trends in Biochemical Sciences·María Almena, Isabel Mérida

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