Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival

The European Respiratory Journal
C M OhriP Bradding

Abstract

There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. The primary aim of the present study was to determine the immunological phenotype of NSCLC-associated macrophages. CD68(+) macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. The islet density of both M1 and M2 macrophages was markedly increased in extended compared with poor survival patients. In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. The 5-yr survival for patients with above and below median expression of M1 macrophages in the islets was >75 and <5%, respectively. Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. The surviv...Continue Reading

Citations

Nov 8, 2011·Cancer Immunology, Immunotherapy : CII·Neil L BerinsteinJohn W Hadden
Nov 28, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·David M RichardsMarkus Feuerer
Dec 20, 2011·Journal of Translational Medicine·Moniek Heusinkveld, Sjoerd H van der Burg
Oct 4, 2013·Immunotherapy·Roheena Z PanniDavid G DeNardo
Jul 22, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shogo KumagaiCheng-Long Huang
Nov 15, 2011·Cellular and Molecular Life Sciences : CMLS·Thomas SchmidtSonja Loges
Feb 20, 2015·Journal of Functional Biomaterials·Isaac M Adjei, Sharma Blanka
May 28, 2015·British Journal of Pharmacology·Steven BozinovskiDaniel Steinfort
Jul 7, 2015·Biochimica Et Biophysica Acta·Qods LahmarJo A Van Ginderachter
Aug 31, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yoichi OhtakiAtsushi Ochiai
Dec 16, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dermot S O'CallaghanKenneth J O'Byrne
Dec 22, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Roy M BremnesLill-Tove Busund
Mar 5, 2016·Mediators of Inflammation·Mario Orozco-MoralesOscar Arrieta
Apr 2, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andreas CarusFrede Donskov
Mar 16, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·L A LievenseJ P J J Hegmans
Nov 20, 2015·American Journal of Respiratory and Critical Care Medicine·Emma M ConwayKevin L Bennewith
Nov 10, 2015·Journal of Theoretical Biology·Nicoline Y den Breems, Raluca Eftimie
Jun 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Alexander HedbrantAnn Erlandsson
Mar 12, 2016·Nature Reviews. Cancer·Sjoerd H van der BurgCornelis J M Melief
Sep 25, 2015·Scientific Reports·Ang YuanPan-Chyr Yang
Dec 17, 2011·International Journal of Cancer. Journal International Du Cancer·Fu-Tsai ChungHan-Pin Kuo
Mar 1, 2012·International Journal of Cancer. Journal International Du Cancer·Maciej Bogdan ManieckiHolger Jon Møller
Nov 29, 2013·Journal of Cellular and Molecular Medicine·Francesco PantanoDaniele Santini
Jun 7, 2013·International Journal of Cancer. Journal International Du Cancer·P J de Vos van SteenwijkE S Jordanova
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Edith M G van EschSjoerd H van der Burg
Aug 25, 2015·Biochimica Et Biophysica Acta·Hassan Lemjabbar-AlaouiPetra Buchanan
Apr 12, 2013·Mediators of Inflammation·Andrzej EljaszewiczWojciech Zegarski
Sep 1, 2015·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·S A AlmatroodiD S Pouniotis
Dec 23, 2011·Clinical & Developmental Immunology·Oana DraghiciuToos Daemen

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