Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis

Thrombosis and Haemostasis
Wonhwa LeeJong-Sup Bae

Abstract

Sepsis develops because of overwhelming inflammatory responses to bacterial infection, and disrupts vascular integrity. Stabilin-1 (STAB-1) is a phagocytic receptor, which mediates efferocytosis in a phosphatidylserine (PS)-dependent manner. STAB-1 is expected to play important roles in efferocytosis during sepsis. Here, we determined the role of STAB-1 in maintaining and restoring vascular integrity. Macrophages and vascular endothelial cells were used to assess the effect of STAB-1 on survival rate, phagocytic activity, vascular permeability and transendothelial migration (TEM). Additionally, we investigated whether the high-mobility group box 1 (HMGB1)-receptor for advanced glycated end products complex interfered with the binding of Stab1 to PS. Mortality rate was higher in the Stab1-knockout mice than in the wild-type mice, and STAB-1 deficiency was related to reduced macrophage-mediated efferocytosis and the disruption of vascular integrity, which increased vascular permeability, and enhanced TEM. STAB-1 deficiency promoted lung injury, and elevated the expression of sepsis markers. The exogenous application of the anti-HMGB1 neutralizing antibody improved efferocytosis, vascular integrity and survival rate in sepsis. Col...Continue Reading

Citations

May 2, 2020·Journal of Cellular Physiology·Kyung-Min KimJong-Sup Bae
Aug 23, 2019·Biomolecules·Seung-Yoon Park, In-San Kim
Apr 1, 2020·Cellular & Molecular Biology Letters·Mehri Bemani NaeiniAmirhossein Sahebkar
Oct 4, 2020·International Journal of Molecular Sciences·Soon-Young KimJung-Eun Kim
Jun 26, 2021·Pharmacology & Therapeutics·Jody Tori O Cabrera, Ayako Makino

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