Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres

Journal of Biomedical Materials Research. Part a
Guobao Wei, Peter X Ma

Abstract

Scaffolds are crucial to tissue engineering/regeneration. In this work, a technique combining a unique phase-separation process with a novel sugar sphere template leaching process has been developed to produce three-dimensional scaffolds. The resulting scaffolds possess high porosities, well connected macropores, and nanofibrous pore walls. The technique advantageously controls macropore shape and size by sugar spheres, interpore opening size by assembly conditions (time and temperature of heat treatment), and pore wall morphology by phase-separation parameters. The bioactivity of a macroporous and nanofibrous poly(L-lactic acid) (PLLA) scaffold was demonstrated by the bone-like apatite deposition throughout the scaffold in a simulated body fluid (SBF). Preincorporation of nanosized hydroxyapatite eliminated the induction period and facilitated the apatite growth in the SBF. Interestingly, the apatite growth primarily occurred on the surface of the pores (internal and external) but not the interior of the nanofibrous network away from the pore surface. It was also noticed that the macropore size did not affect the apatite growth rate, while the interpore opening size did. The compressive modulus also increased substantially whe...Continue Reading

References

Aug 1, 1992·Journal of Biomedical Materials Research·S D CookJ F Kay
Jan 1, 1988·The Journal of Bone and Joint Surgery. British Volume·R G GeesinkC P Klein
Jul 1, 1997·Journal of Biomedical Materials Research·S L IshaugA G Mikos
May 13, 1999·Journal of Biomedical Materials Research·R Zhang, P X Ma
Jun 5, 1999·Journal of Biomedical Materials Research·P X Ma, R Zhang
Aug 22, 2000·Journal of Biomedical Materials Research·R Zhang, P X Ma
Jun 16, 2001·Journal of Biomedical Materials Research·P X Ma, R Zhang
Aug 16, 2001·Journal of Biomedical Materials Research·L SunA Kucuk
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Kyung Mi WooPeter X Ma
Apr 21, 2004·Annals of Biomedical Engineering·Xiaohua Liu, Peter X Ma
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·J X LuB Thierry
Oct 7, 2004·Macromolecular Bioscience·Ruiyun Zhang, Peter X Ma

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Citations

Jan 15, 2011·Pharmaceutical Research·Jiang Hu, Peter X Ma
May 6, 2008·Tissue Engineering. Part B, Reviews·Jungwoo LeeNicholas A Kotov
Sep 2, 2008·Tissue Engineering. Part a·Michelle NgiamCasey K Chan
Mar 10, 2012·Tissue Engineering. Part a·Ami R AminiSyam P Nukavarapu
Aug 11, 2011·Journal of Dental Research·M J Gupte, P X Ma
Mar 3, 2015·Science China. Chemistry·Guo BaoLin, Peter X Ma
May 27, 2014·Journal of Neurosurgery. Spine·Ganjun FengMelanie J Gupte
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Yiin-Kuen FuhWei-Wen Hu
Jan 19, 2013·Expert Opinion on Biological Therapy·Zhanpeng ZhangPeter X Ma
Nov 21, 2014·Journal of Anatomy·Eleanor Knight, Stefan Przyborski
Oct 11, 2015·Journal of Biomedical Materials Research. Part a·Jakub JaroszewiczStanisław Moskalewski
May 15, 2012·Advanced Drug Delivery Reviews·Zhanpeng ZhangPeter X Ma
Mar 22, 2012·Advanced Drug Delivery Reviews·G PagniW V Giannobile
Aug 3, 2010·Biomaterials·Jiang HuPeter X Ma
Feb 11, 2009·Biomaterials·Peng WangPeter X Ma
Nov 30, 2007·Advanced Drug Delivery Reviews·Peter X Ma
Sep 18, 2007·Journal of Biotechnology·Tomoyuki UchidaFumihito Arai
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·I O SmithP X Ma
Nov 10, 2012·Biotechnology Journal·Dan KaiSeeram Ramakrishna
Aug 31, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yong Yang, Kam W Leong
Sep 9, 2010·Biotechnology and Bioengineering·Jeanette BierwolfJoerg M Pollok
Sep 29, 2011·Biomaterials·Jeremy M Holzwarth, Peter X Ma
Jul 4, 2015·Nanomedicine·Dave Wei-Chih Chen, Shih-Jung Liu
Nov 19, 2015·Journal of Cellular Biochemistry·Saja A Al-DujailiLaurie K McCauley
May 28, 2016·Nanomedicine·Zhanpeng ZhangPeter X Ma
Jun 9, 2016·Development, Growth & Differentiation·Takashi Miura, Ryuji Yokokawa
Oct 19, 2017·Journal of Functional Biomaterials·Harrison T Pajovich, Ipsita A Banerjee
Jan 10, 2018·Journal of Biomedical Materials Research. Part a·Birru BhaskarGwendolen C Reilly

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