Macroporous hydrogel membranes for a hybrid artificial pancreas. II. Biocompatibility

Journal of Biomedical Materials Research
G F KlompW H Dobelle

Abstract

A histological evaluation of the biocompatibility of a new porous hydrogel membrane made of 2-hydroxyethyl methacrylate (2-HEMA) was performed. Isolated membranes and diffusion chambers made of this material and filled with rabbit pancreas were implanted in diabetic rats for periods of up to 8 1/2 months. Histologic evaluation showed that this polymer elicits minimal tissue reaction within the first 7 weeks but some increase in granulation tissue and fibrosis thereafter. A component of this tissue reaction is neovascularization, and many blood vessels were noted immediately adjacent to the membrane's surface. Calcification of the membrane was also progressive but could be minimized by formulations resulting in the incorporation of acid groups throughout the hydrogel and on its surface. Diffusion chambers made of this new material show promise for use in a "hybrid" artificial pancreas for the treatment of diabetes.

References

May 1, 1975·Journal of Biomedical Materials Research·R M Rubin, J L Marshall
Jan 1, 1979·Transactions - American Society for Artificial Internal Organs·G F KlompW H Dobelle
Jan 1, 1973·Journal of Biomedical Materials Research·L SprinclJ Kopecek
Dec 1, 1967·Journal of Biomedical Materials Research·J HubacekJ Hubacek
Jun 1, 1969·Journal of Biomedical Materials Research·M TollarK Kliment
Sep 1, 1983·Journal of Biomedical Materials Research·S H RonelW H Dobelle

❮ Previous
Next ❯

Citations

Jan 1, 1992·Biomaterials·G J ZondervanR van Schilfgaarde
Dec 17, 2009·Tissue Engineering. Part a·Sophie VériterDenis Dufrane
Feb 1, 1993·The Journal of Pharmacy and Pharmacology·G M VandenbosscheJ P Remon
Jun 27, 2007·Journal of Pharmaceutical Sciences·Biancamaria Baroli
Oct 15, 2013·Macromolecular Rapid Communications·Pengcheng Yang, Steven P Armes
Sep 1, 1983·Journal of Biomedical Materials Research·S H RonelW H Dobelle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Langmuir : the ACS Journal of Surfaces and Colloids
Pengcheng Yang, Steven P Armes
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jun Jim Wu, Pang N Shek
Journal of Pharmaceutical Sciences
M V Sefton, E Nishimura
Journal of Biomedical Materials Research
K KlimentB Stockar
© 2021 Meta ULC. All rights reserved