Macroporous ordered titanium dioxide (TiO2) inverse opal as a new label-free immunosensor

Analytica Chimica Acta
Jianlin LiZuhong Lu

Abstract

Photonic crystal sensing materials have been validated that they are very sensitive to refractive index changes. Herein, three-dimensionally ordered macroporous (3DOM) (>50 nm) TiO2 inverse opal film has been fabricated by the self-assembly technique. Based on the TiO2 inverse opal film, the optical spectrometer was established for label-free immunosensor. The sensing performance of the 3DOM TiO2 was investigated using human IgG/goat anti-human IgG couple, which showed that the sensitivity of 3DOM TiO2 inverse opal film could reach to 1 microg mL(-1) (equivalent to 1.5 pg mm(-2)) of protein concentration detection limit. The 3DOM TiO2 inverse opal has a large internal surface area, low fluorescence background and unique optical properties. These characteristics indicated the feasibility of 3DOM TiO2 inverse opal in label-free immunoassay.

References

Aug 24, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Songqin Liu, Aicheng Chen

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Citations

Jan 30, 2014·Angewandte Chemie·Christoph FenzlOtto S Wolfbeis
Jul 19, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Sung-Gyu ParkSeung-Man Yang
Dec 5, 2018·Analytical Chemistry·Juan XieHu Wang

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