PMID: 7088281Jan 1, 1982Paper

Macroprolactinomas: CT evaluation of reduction of tumor size after medical treatment

Neuroradiology
G ScottiD Dallabonzana

Abstract

Thirty patients with macroprolactinomas were treated with dopaminergic drugs from a minimum of 4 months to a maximum of 6 years. Tumor size was evaluated with serial CT during treatment; serum prolactin levels and visual fields were also assessed at the same time. Reduction of PRL levels was found in 28 patients of whom 20 also had marked reduction of tumor volume on CT. Two patterns of reduction of size of tumor in relation with time were observed. In one, tumor shrinkage occurred rapidly in the first month and even in the first week after starting treatment. In the other pattern the tumor reduced in size only after some months of treatment. It is proposed that all patients with macroprolactinomas should be treated medically before considering surgery. A radiological diagnostic and research protocol is proposed, including scout views, thin slices, coronal sections, objective measurement of tumor size and density, serial CTs at 7,21,45 days, 6 months and then every year after the beginning of treatment.

Related Concepts

Parlodel
Lisuride, (8alpha)-(+-)-Isomer
Pituitary Carcinoma
Prolactin
Tomography, X-Ray Computerized Axial

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.