PMID: 7539880Feb 1, 1995Paper

Macroregenerative nodules in cirrhosis are not associated with elevated serum or stainable tissue alpha-fetoprotein

Liver
N D TheiseS N Thung

Abstract

We have explored the relationship of serum alpha-fetoprotein and macroregenerative nodules (MRNs), possible precursor lesions of hepatocellular carcinoma (HCC), and sought to demonstrate alpha-fetoprotein (AFP) expression in these nodules. One hundred and sixty-eight sequential adult cirrhotic resected livers were examined and MRNs were identified by standard criteria. Pretransplant serum AFP was available for 158 of these patients (normal < 20 ng/ml). One hundred and seventy-two randomly selected lesions, including ordinary and atypical MRNs, some containing microfoci of HCC, and HCCs were stained for AFP by immunohistochemistry. In the series, 12 cases had grossly apparent HCCs, four associated with high serum alpha-fetoprotein (p < 0.006). Forty-four cases had MRNs, 32 without grossly apparent HCC. Five of these 32 cases were associated with high serum AFP (not significant). Immuno-staining for AFP was seen in three specimens of HCC and in a cirrhotic nodule from a patient without HCC, but not in MRNs. 1) Neither the presence of MRNs--whether ordinary, atypical, or containing micro-foci of HCC--nor that of gross HCC is ruled out by a normal serum AFP. 2) Elevated serum AFP is not associated with the presence of MRNs. 3) MRNs...Continue Reading

References

Aug 22, 1975·Annals of the New York Academy of Sciences·S SakamotoT Wada
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D TheiseS N Thung
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L FerrellN Ascher
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Taketa

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Citations

Aug 26, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Aileen Wee
Jul 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·G LetoN Gebbia
Jun 30, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·L Ferrell
Jun 3, 2011·Archives of Pathology & Laboratory Medicine·Young Nyun Park
Jul 19, 2002·Clinics in Liver Disease·Neil D TheiseMasamichi Kojiro

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