PMID: 5919360Sep 1, 1966

Macroscopic identification of early myocardial infarction by dehydrogenase alterations

Journal of Clinical Pathology
R A Ramkissoon

Abstract

A method utilizing a general dehydrogenase reaction has been used to demonstrate early gross myocardial infarctions. The procedure takes advantage of substrate and enzyme loss from the damaged myocardium. In the viable muscle, where endogenous substrates, coenzymes, and dehydrogenases are present, reduction of Nitro-BT yields a dark blue formazan. Necrotic muscle fibres remain unstained by this technique.A survey of 31 human hearts obtained at necropsy disclosed that there is no alteration in the Nitro-BT reaction following acute coronary insufficiency with sudden death or severe congestive heart failure. The earliest myocardial infarct to show loss of dehydrogenase activity was of eight hours' duration. Post-infarction scars and patchy interstitial fibrosis provided very precise information concerning topographic relationships when this method was applied to heart slices.

References

Jan 1, 1961·Circulation·M W HAMOLSKY, N O KAPLAN
Mar 1, 1962·American Journal of Clinical Pathology·M D GRAVES ROSSA

Citations

Jan 1, 1984·Acta Neuropathologica·T M LiszczakN T Zervas
Apr 1, 1970·Journal of Clinical Pathology·J G McVie
Apr 1, 1988·Medical Informatics = Médecine Et Informatique·Y NoseM Nakamura
Oct 2, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nicholas DanaRichard Bouchard
Mar 2, 2010·Journal of Pharmacological and Toxicological Methods·Csaba CsonkaP Ferdinandy
Sep 1, 1985·Histopathology·A C Thomas, M J Davies
Jan 29, 2000·The Journal of the American Association of Gynecologic Laparoscopists·J D DobakD E Townsend
Jan 29, 2000·The Journal of the American Association of Gynecologic Laparoscopists·J D Dobak, J Willems
Apr 4, 2006·Journal of Pharmacological and Toxicological Methods·Philipe N KhalilHans Fritz
Jun 24, 2004·European Journal of Pharmacology·Tijl De CelleBen J Janssen
Jun 1, 1992·The Journal of Pathology·W A ReidI Barnes
Aug 21, 2013·The American Journal of Forensic Medicine and Pathology·Yu KakimotoKeiji Tamaki
May 1, 1978·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·B F Hansen

Related Concepts

Myocardial Infarction
Myocardium
Oxidase

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