PMID: 11339926May 8, 2001Paper

Macrosomia associated with maternal serum insulin-like growth factor-I and -II in diabetic pregnancy

Obstetrics and Gynecology
F F LauszusA Flyvbjerg

Abstract

To determine the possible relation between maternal serum insulin-like growth factor I and II (IGF-I and IGF-II) in women with insulin-dependent diabetes mellitus and fetal macrosomia. This was a prospective, observational study of 45 pregnant women with insulin-dependent diabetes mellitus without overt nephropathy, examined in an outpatient, antenatal diabetic clinic. Maternal venous serum samples were collected from week 14 every fourth week until week 30, and every other week until delivery. Levels of IGF-I and -II were measured in maternal serum by immunoassays. The repeated measurements were tested with two-way analysis of variance. The outcome measures were birth weight and serum IGF-I, IGF-II, IGF binding protein (BP)-3, and IGFBP-3 proteases. Before the study, minimum sampling size was calculated as 14 subjects in each group if a difference in IGF-I of 50 microg/L was to be detected with an estimated standard deviation of 40, a two-sided P value (alpha) of.05, and a power of 90 (beta =.1). Increasing levels of IGF-I and -II were significantly associated with the birth-weight groups: The higher the birth-weight ratio, the higher the levels of IGF-I and -II (P <.01). Macrosomia in diabetic pregnancy is associated with hig...Continue Reading

References

Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·P HossenloppM Binoux

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Citations

Jul 22, 2004·Current Diabetes Reports·David A Sacks
Apr 14, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Lorin Lakasing, Catherine Williamson
Jun 2, 2005·Seminars in Fetal & Neonatal Medicine·Stephen A Walkinshaw
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Apr 1, 2013·Journal of Developmental Origins of Health and Disease·F GaccioliT Jansson
Nov 26, 2004·Journal of Clinical Pathology·A R HayatiW M Norizah
Feb 10, 2016·Frontiers in Physiology·Kris Genelyn DimasuayThomas Jansson
Jun 5, 2012·Reproductive Toxicology·Asher Ornoy
Jun 6, 2006·Early Human Development·Abdul Rahman HayatiGeok Chin Tan

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