Macrostructural and Microstructural Brain Lesions Relate to Gait Pathology in Children With Cerebral Palsy

Neurorehabilitation and Neural Repair
Pieter MeynsEls Ortibus

Abstract

Background Even though lower-limb motor disorders are core features of spastic cerebral palsy (sCP), the relationship with brain lesions remains unclear. Unraveling the relation between gait pathology, lower-limb function, and brain lesions in sCP is complex for several reasons; wide heterogeneity in brain lesions, ongoing brain maturation, and gait depends on a number of primary motor functions/deficits (eg, muscle strength, spasticity). Objective To use a comprehensive approach combining conventional MRI and diffusion tensor imaging (DTI) in children with sCP above 3 years old to relate quantitative parameters of brain lesions in multiple brain areas to gait performance. Methods A total of 50 children with sCP (25 bilateral, 25 unilateral involvement) were enrolled. The investigated neuroradiological parameters included the following: (1) volumetric measures of the corpus callosum (CC) and lateral ventricles (LVs), and (2) DTI parameters of the corticospinal tract (CST). Gait pathology and primary motor deficits, including muscle strength and spasticity, were evaluated by 3D gait analysis and clinical examination. Results In bilateral sCP (n = 25), volume of the LV and the subparts of the CC connecting frontal, (pre)motor, an...Continue Reading

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Citations

Apr 4, 2017·Frontiers in Human Neuroscience·Joanne ZhouJessica Rose
Jan 10, 2018·Frontiers in Human Neuroscience·Lisa MailleuxHilde Feys
Aug 1, 2020·Frontiers in Human Neuroscience·Eirini PapageorgiouEls Ortibus
Jul 18, 2019·Frontiers in Human Neuroscience·Pieter MeynsKaat Desloovere
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Apr 8, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Brian C Clark, Richard G Carson
Jul 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shahla AziziMehdi M Mirbagheri

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