Macrovascular contribution in activation patterns of working memory.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Dardo Tomasi, E C Caparelli

Abstract

Brain activation maps of blood oxygenation level dependent (BOLD) signals during functional magnetic resonance imaging (fMRI) are sensitive to unwanted contributions from large vessels. Most BOLD-fMRI studies are based on a stimulus-correlated modulation of the MRI signal amplitude that is sensitive to desired microvascular effects and unwanted macrovascular effects. Aiming to suppress macrovascular effects in activation patterns, this BOLD-fMRI study evaluates brain activation during a verbal working memory task (2-back) in healthy volunteers (n=18) using the amplitude and phase components of the MRI signal. The use of the first time point as a phase reference allowed us to eliminate phase wrapping artifacts and increase the statistical power of 'phase' activation, and this information was used to filter out voxels with significant macrovascular (i.e., draining and pial veins) contribution in 'amplitude' activation patterns. Across subjects, the task produced large modulations of the relative phase in the occipital, dorsolateral prefrontal, and parietal cortices, suggesting a common distribution of draining veins in these regions across subjects, and in the rostral frontal cortex, probably associated to stimulus-correlated mot...Continue Reading

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Citations

Feb 2, 2011·Cerebral Cortex·Dardo Tomasi, Nora D Volkow
Aug 16, 2008·Journal of Neuroscience Methods·John SucklingEdward Bullmore
Jun 22, 2007·Psychiatry Research·Dardo TomasiNora D Volkow
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Mar 20, 2016·Journal of Neuroscience Methods·Wei DuTülay Adalı
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Jun 20, 2014·NeuroImage·Dávid Z BallaRichard Bowtell
Apr 11, 2015·Journal of Neuroscience Methods·Mou-Chuan YuVince D Calhoun
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Feb 11, 2016·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Sudhakar R SattiSonya N Tuerff

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