Macula densa stimulation of renin is reversed by selective inhibition of neuronal nitric oxide synthase

The American Journal of Physiology
W H Beierwaltes

Abstract

The neuronal isoform of nitric oxide synthase (nNOS) exists in the renal cortex predominantly in the macula densa, suggesting that nitric oxide (NO) derived from the macula densa plays a role in feedback regulation of renin in response to altered sodium metabolism. To determine if nNOS is a critical component in renin stimulation induced by dietary sodium restriction, rats received either normal sodium or a sodium-restricted diet (0.03%) for 7 days and subsequently were or were not treated with the selective inhibitor of nNOS 7-nitroindazole (7-NI) either acutely (50 mg/kg body wt ip) on the final day or chronically (20 mg/kg body wt ip 2 x/day) over the final 5 days. On the last day, rats were anesthetized with Inactin and fitted with arterial and renal venous catheters to collect blood and monitor blood pressure (BP) and a flow probe to measure renal blood flow (RBF). BP (105 vs. 108 mmHg) was similar in normal and low-sodium dietary groups, respectively, whereas RBF tended to be higher in the sodium-restricted group (6.5 +/- 0.3 vs. 7.6 +/- 0.4 ml.min-1.g kidney wt-1). Both renal venous renin (RR) and renin secretion rate (RSR) were elevated approximately fourfold by sodium restriction [RR = 5.8 +/- 0.8 vs. 20.5 +/- 2.7 ng a...Continue Reading

Citations

Jun 16, 2001·American Journal of Physiology. Renal Physiology·R C Harris, M D Breyer
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M KakokiD L Mattson
Jun 1, 2012·American Journal of Physiology. Endocrinology and Metabolism·Douglas K AtchisonWilliam H Beierwaltes
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M Sayago, W H Beierwaltes
Jun 17, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rosemary WangensteenFélix Vargas
Dec 12, 2001·American Journal of Physiology. Renal Physiology·William H BeierwaltesEdward G Shesely
Feb 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A PaliegeS Bachmann
Jul 31, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Julian M StewartIndu Taneja
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann
Feb 2, 2006·American Journal of Physiology. Renal Physiology·William H Beierwaltes
Oct 13, 2010·Annual Review of Physiology·Armin Kurtz
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L Mattson, Carla J Meister
Jul 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas K AtchisonWilliam H Beierwaltes
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S R AbramJ P Granger
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
Jul 15, 2000·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Mar 11, 2004·American Journal of Physiology. Renal Physiology·Alex PaliegeTianxin Yang
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner

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