Macula Ganglion Cell Thickness Changes Display Location-Specific Variation Patterns in Intermediate Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science
Matt TrinhLisa Nivison-Smith

Abstract

The purpose of this study was to examine changes in the ganglion cell layer (GCL) of individuals with intermediate age-related macular degeneration (AMD) using grid-wise analysis for macular optical coherence tomography (OCT) volume scans. We also aim to validate the use of age-correction functions for GCL thickness in diseased eyes. OCT macular cube scans covering 30° × 25° were acquired using Spectralis spectral-domain OCT for 87 eyes with intermediate AMD, 77 age-matched normal eyes, and 254 non-age-matched normal eyes. The thickness of the ganglion cell layer (GCL) was defined after segmentation at 60 locations across an 8 × 8 grid centered on the fovea, where each grid location covered 0.74 mm2 (approximately 3° × 3°) within the macula. Each GCL location of normal eyes (n = 77) were assigned to a specific iso-ganglion cell density cluster in the macula, based on patterns of age-related GCL thickness loss. Analyses were then performed comparing AMD GCL grid-wise data against corresponding spatial clusters, and significant AMD GCL thickness changes were denoted as values outside the 95% distribution limits. Analysis of GCL thickness changes revealed significant differences between spatial clusters, with thinning toward the f...Continue Reading

References

Sep 1, 1986·American Journal of Optometry and Physiological Optics·B BrownA Colenbrander
Jul 1, 1997·Journal of Neurocytology·T I ChaoA Reichenbach
Apr 4, 1998·Acta Ophthalmologica Scandinavica·J OlssonA Heijl
Apr 6, 2005·Ophthalmology·Traci E ClemonsUNKNOWN Age-Related Eye Disease Study Research Group
May 26, 2007·Investigative Ophthalmology & Visual Science·Robert K P SullivanDavid V Pow
Oct 10, 2009·Ophthalmology·Maria Laura GomezWilliam R Freeman
Jan 22, 2013·Ophthalmology·Frederick L FerrisUNKNOWN Beckman Initiative for Macular Research Classification Committee
Jan 26, 2013·The Journal of Comparative Neurology·Jacqueline ChuaMichael Kalloniatis
Jan 31, 2013·Investigative Ophthalmology & Visual Science·Sam SadighSamuel G Jacobson
Oct 8, 2013·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Elisabetta PilottoEdoardo Midena
Jan 11, 2014·Investigative Ophthalmology & Visual Science·Maria Cristina SavastanoBenedetto Falsini
Jun 19, 2015·Investigative Ophthalmology & Visual Science·Eun Kyoung Lee, Hyeong Gon Yu
Apr 6, 2016·The British Journal of Ophthalmology·Ferdinand G SchlanitzUrsula Schmidt-Erfurth
May 21, 2016·Frontiers in Cellular Neuroscience·Bryan W JonesRobert E Marc
May 16, 2017·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Pedro CamachoLiliana Páris
Jun 19, 2017·American Journal of Ophthalmology·Enrico BorrelliSriniVas R Sadda
Jun 21, 2017·Investigative Ophthalmology & Visual Science·Nayuta YoshiokaMichael Kalloniatis
Apr 4, 2018·Investigative Ophthalmology & Visual Science·Nayuta YoshiokaMichael Kalloniatis
Aug 11, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ilkay Kilic MuftuogluWilliam R Freeman
Sep 11, 2018·Translational Vision Science & Technology·Jack PhuMichael Kalloniatis
Jan 11, 2019·Scientific Reports·Aldenor G SantosJailson B de Andrade
Apr 18, 2019·Investigative Ophthalmology & Visual Science·Caroline BrandlKlaus J Stark
Aug 14, 2019·Translational Vision Science & Technology·Matt TrinhLisa Nivison-Smith

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Software Mentioned

HRA
GraphPad
Spectralis
GraphPad Prism

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