PMID: 7547785Aug 1, 1995Paper

Macular blood flow velocity in sickle cell disease: relation to red cell density

The British Journal of Ophthalmology
M S RoyD Giuliani

Abstract

While the retinal lesions of sickle cell retinopathy have been well documented, their pathogenesis remains unclear. The purpose of this study was (1) to compare macular blood flow velocity in patients with sickle cell disease and controls, and (2) to determine in sickle cell patients the relation between macular blood flow velocity and red blood cell density. Macular blood flow velocity was measured in 18 patients with stable sickle cell disease and 45 normal controls using blue field entoptoscopy. Red blood cell density was determined by the phthalate ester density method. There were no significant differences between patients and controls for leucocyte velocity. However, in the sickle cell patients leucocyte velocity in the macular capillaries was significantly negatively associated with greater range of red blood cell density (p < 0.002 and p < 0.04 for right and left eyes, respectively). These results suggest that in sickle cell patients heterogeneity of the density of the red blood cells may slow down macular capillary blood flow.

References

Jul 29, 1977·Pflügers Archiv : European journal of physiology·J Heller, V Horácek
Jul 1, 1986·The British Journal of Ophthalmology·B E SerjeantG R Serjeant
Jan 1, 1989·The British Journal of Ophthalmology·T RimmerE M Kohner
Jan 1, 1986·The British Journal of Ophthalmology·T J FallonE M Kohner
Aug 1, 1985·The British Journal of Ophthalmology·M S RoyA N Schechter
Jul 1, 1973·Archives of Ophthalmology·M F Goldberg, I Acacio
Apr 1, 1972·American Journal of Ophthalmology·P I Condon, G R Serjeant
Mar 1, 1971·American Journal of Ophthalmology·M F Goldberg
Mar 1, 1966·Archives of Ophthalmology·R B Welch, M F Goldberg
Jan 1, 1981·The British Journal of Ophthalmology·R J HayesG R Serjeant
Nov 1, 1983·The British Journal of Ophthalmology·J F TalbotG R Serjeant
Jan 1, 1980·Microvascular Research·G W Schmid-SchönbeinS Chien
Jun 1, 1980·The British Journal of Ophthalmology·P I Condon, G R Serjeant
Oct 1, 1980·Journal of the Optical Society of America·C E Riva, B Petrig

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Citations

May 11, 2010·Survey of Ophthalmology·Mohammed ElagouzSobha Sivaprasad
Nov 29, 2014·Acta Ophthalmologica·Ali Kord ValeshabadMahnaz Shahidi
Feb 27, 2017·La Revue de médecine interne·A K DembéléD A Diallo
Jul 25, 2019·The British Journal of Ophthalmology·Giselle LynchToco Y Chui
Apr 5, 2018·Clinical Hemorheology and Microcirculation·Carlo Brugnara

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