Macular development in the premature infant

American Journal of Ophthalmology
S J Isenberg

Abstract

To classify the ophthalmoscopic appearance of the developing macula, I performed retinal examinations on 129 premature neonates. In normal infants, the classification ranged from 34 weeks of gestational age when pigment was first evident in the macula, through the development of the annular ring reflex of the macula and foveolar reflex, to a mature (adult-appearing) macula at 42 weeks. This sequence allowed the observer to estimate the gestational age of the older premature neonate from the appearance of the macular area. Babies who had, or subsequently developed, retinopathy of prematurity showed a statistically significant two-week delay in macular development in the later stages. This may be the first evidence of a direct macular insult in retinopathy of prematurity.

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Citations

Jul 18, 2003·Ophthalmology·Sherwin J IsenbergJean-Pierre Guillon
Jun 8, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Rain G BosworthKaren R Dobkins
Aug 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M E HartnettO Katsumi
Mar 24, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kyoung Min LeeYoung Suk Yu
Feb 11, 1992·Ophthalmology·S W NoorilyR Machemer
Aug 1, 1988·Ophthalmology·S M Archer
Aug 18, 2012·American Journal of Ophthalmology·Lejla VajzovicCynthia A Toth
Dec 6, 2011·Ophthalmology·Sherwin J Isenberg
Sep 24, 2011·Ophthalmology·Ramiro S MaldonadoCynthia A Toth
Jul 1, 2009·Progress in Retinal and Eye Research·Anne B FultonJames D Akula
Apr 1, 1991·The Journal of Pediatrics·S J Isenberg
Apr 26, 2003·Pediatric Clinics of North America·Deepak P Edward, Lawrence M Kaufman
May 17, 2002·Seminars in Neonatology : SN·E E Birch, A R O'Connor
Jul 15, 2015·BioMed Research International·Hemang K PandyaKimberly A Drenser
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Jan 1, 2001·The American Orthoptic Journal·A R O'ConnorT J Stephenson
Jul 13, 2021·Ophthalmology·Michael F ChiangAndrea Zin

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