Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease

Investigative Ophthalmology & Visual Science
Sally S OngCynthia A Toth

Abstract

To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease. Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 2016 were reviewed for SD-OCT features. Central subfield (CSF) SD-OCT findings were analyzed relative to VA (logarithm of the minimum angle of resolution) at baseline and final visit (when follow-up ≥ 6 months) and across visits. Mean VA ± standard deviation at baseline (37 eyes) was 0.92 ± 0.82. SD-OCT features associated with worse VA included, for treatment-naïve eyes (n = 21), outer retinal atrophy (ORA) (1.18 ± 0.34 with versus 0.20 ± 0.30 without, P = 0.005), subretinal fluid (SRF) (1.80 ± 0.63 vs. 0.63 ± 0.50, P = 0.008), bright hyperreflectivities (1.23 ± 0.68 vs. 0.52 ± 0.53, P = 0.02), thicker foveal subretinal space (r2 = 0.32, P = 0.01), and CSF (r2 = 0.39, P = 0.007); and for previously treated eyes (n = 16), a compact hyperreflective structure (1.60 ± 0.88 vs. 0.56 ± 0.64, P = 0.02) and ORA (1.34 ± 0.86 vs. 0.30 ± 0.44, P = 0.01). At final follow-up (n = 22), mean VA was 0.81 ± 0.83. Eyes with final VA <20/200 (n = 6, vs. >20/60, n = 11) more commonly had a compact hyperreflective st...Continue Reading

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Citations

Nov 27, 2018·JAMA Ophthalmology·Irena Tsui, Stacy L Pineles
Jul 18, 2020·BMJ Case Reports·Subhakar ReddyPadmaja Kumari Rani
Feb 23, 2020·Therapeutic Advances in Ophthalmology·Bradley S Gundlach, Irena Tsui
Mar 22, 2019·International Ophthalmology·Xinyue YangGuanfang Su
Oct 18, 2020·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Sophie CaiLejla Vajzovic

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