Macular Morphology and Visual Acuity in the Second Year of the Comparison of Age-Related Macular Degeneration Treatments Trials

Ophthalmology
Sumit SharmaComparison of Age-related Macular Degeneration Treatments Trials Research Group

Abstract

To describe the association between morphologic features on fundus photography (FP), fluorescein angiography (FA), and optical coherence tomography (OCT) and visual acuity (VA) in the second year of the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). Prospective cohort study within a randomized clinical trial. Participants in the CATT. Study eye eligibility required angiographic and OCT evidence of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and VA between 20/25 and 20/320. Treatment was assigned randomly to ranibizumab or bevacizumab with 3 different dosing regimens over a 2-year period. Fluid type, location, and thickness; retina and subretinal tissue complex thickness on OCT; size and lesion composition on FP and FA; and VA. Among 1185 CATT participants, 993 (84%) had fluid on OCT at baseline and completed 2 years of follow-up. At 2 years, intraretinal fluid (IRF), subretinal fluid (SRF), sub-retinal pigment epithelium (RPE) fluid, and subretinal tissue complex thickness decreased in all treatment groups. Ranibizumab monthly was best able to resolve each type of fluid. Eyes with SRF in the foveal center on OCT had better mean VA than eyes with no SRF (72.8 v...Continue Reading

References

Feb 16, 2006·Archives of Ophthalmology·Annie ChanJoel S Schuman
Apr 30, 2011·The New England Journal of Medicine·UNKNOWN CATT Research GroupGlenn J Jaffe
May 5, 2012·Ophthalmology·UNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research GroupFrederick L Ferris
May 7, 2013·Ophthalmology·Glenn J JaffeUNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials Research Group
May 21, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Kavita V Bhavsar, K Bailey Freund

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Citations

May 10, 2016·Ophthalmology·UNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research GroupStuart L Fine
Jul 2, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·B BookA Lommatzsch
Jan 28, 2017·Ophthalmology·Glenn J Jaffe, UNKNOWN CATT Research Group
Feb 27, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kunny C DansWilliam R Freeman
Nov 22, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peipei WuPing Lin
Mar 20, 2020·JAMA Ophthalmology·Ebenezer DanielUNKNOWN Comparison of Age-Related Macular Degeneration Treatments Trials Research Group
Mar 6, 2019·The Cochrane Database of Systematic Reviews·Sharon D SolomonBarbara S Hawkins
Sep 26, 2020·Translational Vision Science & Technology·Michael G KawczynskiJeffrey R Willis
Aug 19, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eui Chun KangHyoung Jun Koh
Dec 29, 2019·Ophthalmology and Therapy·Shashikant SharmaUNKNOWN RE-ENACT 2 Study Investigators Group
Apr 20, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C R ClemensN Eter
Dec 29, 2020·American Journal of Ophthalmology·Tiarnan D L KeenanUrsula Schmidt-Erfurth
Nov 23, 2020·American Journal of Ophthalmology·Avni P FinnUNKNOWN Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group
Feb 18, 2021·International Journal of Retina and Vitreous·Robert J MinturnRaj K Maturi

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