Macular optical coherence tomography in patients with unilateral optic nerve hypoplasia

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Javaneh AbbasianMichael P Blair

Abstract

To characterize the extent and location of macular thinning in patients with unilateral optic nerve hypoplasia (ONH) as compared to the contralateral normal eye. The medical records of patients with unilateral ONH who underwent spectral domain optical coherence tomography (SD-OCT) of the macula were retrospectively reviewed. SD-OCT scans were manually segmented by 3 observers in 3 macular regions (superior, central, inferior). Boundaries identified included the inner limiting membrane, the junction between the inner nuclear layer and outer plexiform layer, and the neural retina-retinal pigment epithelium interface. Using custom MATLAB software, inner and outer retinal thickness profiles were quantified. A paired t test was used to compare the retinal thickness between the ONH eye and the contralateral normal eyes. Inner retinal thickness of the ONH eye was decreased in all areas of the macula (superior, central, and inferior) compared to the contralateral normal eye (P < 0.05). Outer retinal thicknesses were also decreased in the central and inferior sections compared with the normal eye (P < 0.05). Optic nerve hypoplasia is a congenital disease known to result in thinning of the nerve fiber and ganglion cell layer. Our small c...Continue Reading

References

Jan 1, 1978·The British Journal of Ophthalmology·L Frisén, L Holmegaard
Aug 1, 1978·Archives of Ophthalmology·M A MosierD L Knox
Sep 1, 1972·Archives of Ophthalmology·H B Gardner, A R Irvine
Jul 1, 1982·The British Journal of Ophthalmology·D Taylor
Sep 7, 1999·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·A HellströmE Svensson
Nov 10, 2006·Journal of Child Neurology·M Lourdes GarciaElias I Traboulsi
Jun 15, 2007·Brain Research·Lisa M Baye, Brian A Link
Aug 19, 2008·American Journal of Ophthalmology·Ahmet Murat BagciRuth Zelkha
Mar 11, 2010·Journal of Clinical Neuromuscular Disease·Anant M ShenoyBrian S Tseng
Apr 17, 2010·Human Molecular Genetics·Stuart MacgregorDavid A Mackey
Dec 21, 2010·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Lan ChangFawn Leigh
Jan 8, 2011·Ophthalmology·Mervyn G ThomasIrene Gottlob
Jun 21, 2011·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Hilda CapoR Michael Siatkowski
Jul 12, 2011·Investigative Ophthalmology & Visual Science·Minako Ogata-IwaoHidenobu Tanihara
Nov 12, 2013·Indian Journal of Ophthalmology·Daruchi Moon, Tae Kwann Park
Jan 24, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Aliza E EpsteinTa C Chang

❮ Previous
Next ❯

Citations

Dec 19, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·John P KellyAvery H Weiss
Aug 18, 2017·Current Opinion in Ophthalmology·Karen W Jeng-MillerEric D Gaier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved