Macular pigment carotenoids in the retina and occipital cortex are related in humans

Nutritional Neuroscience
Rohini VishwanathanElizabeth J Johnson

Abstract

Lutein and zeaxanthin are dietary carotenoids that preferentially accumulate in the macular region of the retina. Together with meso-zeaxanthin, a conversion product of lutein in the macula, they form the macular pigment. Lutein is also the predominant carotenoid in human brain tissue and lutein status is associated with cognitive function in adults. The study objective was to evaluate the relationship between retinal and brain lutein and zeaxanthin in humans. Donated brain tissue (occipital cortex and hippocampus) and matched retina were obtained from the National Disease Research Interchange, a national human tissue resource center which adheres to strict consent and confidentiality procedures. Decedents were men and women aged >50 years who either had normal cognitive function or Alzheimer's disease. Tissues were analyzed using standard lipid extractions followed by analysis on reverse-phase high performance liquid chromatography (HPLC) and normal-phase HPLC (for meso-zeaxanthin). Macular pigment carotenoids (lutein, meso-zeaxanthin, and zeaxanthin combined) in the retina were significantly related to the combined concentrations of lutein and zeaxanthin in the occipital cortex. When analyzed separately, only retinal lutein (...Continue Reading

References

Jan 1, 1989·Free Radical Biology & Medicine·N I Krinsky
Apr 14, 2004·Archives of Ophthalmology·David S FriedmanUNKNOWN Eye Diseases Prevalence Research Group
Mar 8, 2005·Survey of Ophthalmology·Shazia S AhmedDennis M Marcus
May 31, 2008·Nutritional Neuroscience·Elizabeth J JohnsonD Max Snodderly
Sep 8, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Binxing LiPaul S Bernstein
Jul 12, 2012·Nutritional Neuroscience·Rohini VishwanathanElizabeth J Johnson
Oct 12, 2012·The American Journal of Clinical Nutrition·Elizabeth J Johnson
Jan 18, 2014·Age and Ageing·Rohini VishwanathanElizabeth J Johnson
Apr 3, 2014·Journal of Pediatric Gastroenterology and Nutrition·Rohini VishwanathanElizabeth J Johnson

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Citations

Nov 14, 2015·Foods·John W ErdmanMartha Neuringer
Jul 20, 2016·Annual Review of Nutrition·Julie Mares
Jul 12, 2017·Journal of the International Neuropsychological Society : JINS·Cutter A LindberghL Stephen Miller
Aug 5, 2017·Nutrients·Monika A ZielińskaJadwiga Hamułka
Feb 17, 2018·Journal of the American College of Nutrition·Taylor C Wallace
Jun 13, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jirayu TanprasertsukElizabeth J Johnson
Mar 1, 2019·Molecular Nutrition & Food Research·Caitlyn G EdwardsNaiman A Khan
Mar 26, 2019·Annual Review of Food Science and Technology·Rebecca PowerJohn M Nolan
Mar 29, 2019·Molecular Nutrition & Food Research·William OliverBilly R Hammond
Jan 29, 2020·Phytotherapy Research : PTR·Natalia Dos Santos TramontinAlexandre P Muller
Jun 13, 2020·Nutrients·Long Hin LiAmy Cheuk Yin Lo
Jul 20, 2019·Current Developments in Nutrition·James M StringhamB Randy Hammond
Dec 22, 2016·Frontiers in Aging Neuroscience·Marta K ZamroziewiczAron K Barbey
Feb 12, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesco CotaGiovanni Vento
Aug 29, 2020·Oxidative Medicine and Cellular Longevity·Camille Keisha MahendraBey Hing Goh
Dec 24, 2019·Translational Vision Science & Technology·Marina Green-GomezJohn M Nolan
Dec 8, 2020·Neurochemistry International·Padmanabh SinghM K Thakur
Apr 15, 2018·Archives of Biochemistry and Biophysics·Elena Giordano, Loredana Quadro
May 29, 2021·The Journal of Nutrition·Ruyu LiuNaiman A Khan
Jul 10, 2021·Investigative Ophthalmology & Visual Science·Marina Green-GomezJohn Nolan

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