Macular pigment optical density measurement in autofluorescence imaging: comparison of one- and two-wavelength methods.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
M TrieschmannDaniel Pauleikhoff

Abstract

Measurement of macular pigment (MP) can be performed by analysis of autofluorescence (AF) images. These can be obtained by standard 488-nm argon-imaging alone (one wavelength, 1-Lambda) or with additional digital subtraction of a second image at 514 nm (two wavelengths, 2-Lambda). The analyses are easy to perform, and we present a comparison of both methods and investigate their reliability and repeatability. Inter-individual variability of MP optical density (MPOD) measurements was assessed in single eyes of 120 subjects with a modified Heidelberg retina angiograph (HRA). MPOD values obtained with one (488 nm) Lambda (MPOD(1Lambda)) were compared with those obtained with two (488 nm and 514 nm) Lambda (MPOD(2Lambda)). To test the repeatability of the two methods, 20 subjects were subjected to five repeated measurements. Among 120 individuals, mean MPOD(1Lambda) at 0.5 degrees eccentricity was 0.59 (range 0.06-1.32), mean MPOD(2Lambda) was 0.5 (range 0.01-1.21). Apart from this systematic difference, 1-Lambda and 2-Lambda measurements at 0.5 degrees agreed well across the range of MPOD values (beta=0.964, around the fovea, a systematic difference (0.11) was accompanied by declining agreement at higher MPOD values (beta=0.669, 9...Continue Reading

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Citations

Aug 30, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sebastian Wolf
Jan 12, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Olivia HowellsHannah Bartlett
Aug 19, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yuzuru SasamotoKohji Nishida
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Jul 25, 2021·The British Journal of Ophthalmology·Philipp L MüllerCatherine Egan
Aug 15, 2021·Eye·Daniel PauleikhoffEmily Y Chew

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