Abstract
To examine retinal sensitivity in patients on hydroxychloroquine (HCQ) with no evidence of retinopathy. Seventy patients on HCQ and 30 healthy control subjects were included prospectively. All subjects underwent complete ophthalmic examination including best corrected visual acuity, tonometry, colour vision testing, biomicroscopy of anterior segment, dilated fundoscopy, 10-2 visual field testing, and spectral domain optical coherence tomography. The patients and control subjects who met the inclusion criteria and had normal tests underwent microperimetry (MP) testing. First, all patients were compared with the control group. Secondly, patients were divided into three sets of groups based on (1) duration of use ≤5 years (DOU≤5) and >5 years (DOU>5), (2) daily dose ≤5 mg/kg/day (DD≤ 5) and >5 mg/kg/day (DD>5), and (3) a cumulative dose ≤1000 gr (CD≤ 1000) and >1000 gr (CD>1000), and these groups were compared to each other and to the control group. A correlation analysis was also performed between MP sensitivity and DOU, DD, and CD. Seven patients on HCQ showing visual field abnormality were excluded which yielded 63 patients and 30 control subjects for the final analysis. We observed significant differences only in the central r...Continue Reading
References
Jul 14, 2004·Archives of Ophthalmology·Raj K MaturiRichard G Weleber
Nov 29, 2005·American Journal of Ophthalmology·Timothy Y Y LaiDennis S C Lam
Jan 28, 2006·Eye·O YeniceO Orüm
Mar 28, 2009·Investigative Ophthalmology & Visual Science·Fred K ChenLyndon Da Cruz
Apr 18, 2009·Eye·S Pasadhika, G A Fishman
Dec 14, 2011·Archives of Ophthalmology·Michael F Marmor
Mar 30, 2012·Clinical Ophthalmology·Donald F Farrell
Oct 6, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Heather K Burnett, Rizwan Somani
Dec 12, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Michael Easterbrook
Jun 15, 2013·Eye·R V JivrajkaW F Mieler
Oct 8, 2013·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Lucía Martínez-CostaPilar Marco-Ventura
Aug 13, 2014·Clinical Ophthalmology·David J Browning, Chong Lee
Sep 4, 2014·Ophthalmology·Ronald B Melles, Michael F Marmor
Oct 3, 2014·JAMA Ophthalmology·Ronald B Melles, Michael F Marmor
Feb 26, 2015·Ophthalmology·Dong Hoon LeeYoung Hee Yoon
Apr 11, 2015·Journal of Ophthalmology·A Molina-MartínR J Pérez-Cambrodí
May 7, 2015·Oncotarget·Kwan-Hwa ChiShang-Jyh Kao
Jul 23, 2015·Diabetologia·Mary Chester M WaskoFrederico G S Toledo
Sep 16, 2015·Current Medical Research and Opinion·Anil PareekSubhash Saxena
Mar 20, 2016·Ophthalmology·Michael F MarmorUNKNOWN American Academy of Ophthalmology
Jun 15, 2018·Archives of Rheumatology·Mehmet BulutHasan Fatih Çay