Macular thinning in prediabetes or type 2 diabetes without diabetic retinopathy: the Maastricht Study

Acta Ophthalmologica
Eline E B De ClerckCarroll A B Webers

Abstract

To assess macular thinning in individuals with prediabetes or type 2 diabetes without diabetic retinopathy (DM2 w/o DR) compared with individuals with normal glucose metabolism (NGM). Using spectral domain optical coherence tomography (SD-OCT), we measured macular thickness in six subfields as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) in 1838 participants from The Maastricht Study, a population-based cohort study (mean age 59 ± 8 years, 49% men, 1087 NGM, 279 prediabetes, 472 DM2 w/o DR). Multivariable linear regression was used to assess the association between macular thickness and glucose metabolism status. After adjustment for age, sex and spherical equivalent, individuals with prediabetes showed a significant decrease in pericentral superior macular thickness [β = -2.14 μm (95% confidence interval (CI): -4.24 to -0.03), p < 0.05] compared with individuals with NGM. In individuals with DM2 w/o DR, the fovea [β = -4.05 μm (95% CI: -6.30 to -1.79), p < 0.001] and the four pericentral quadrants (range: β = -4.64 to -5.29 μm, p < 0.001) were significantly thinner compared with individuals with NGM. There was a significant linear trend of macular thinning with severity of glucose metabolism status in five...Continue Reading

References

Aug 1, 1979·The British Journal of Ophthalmology·D B Henson, R V North
Nov 1, 1975·The British Journal of Ophthalmology·J Cunha-VazA J Campos
Jul 1, 1986·Archives of Ophthalmology·G H Bresnick
Jan 1, 1985·Archives of Ophthalmology·S SokolB Senior
Dec 1, 1980·Acta Ophthalmologica·K Frost-LarsenS E Simonsen
Mar 31, 1998·Diabetes·M MizutaniM Lorenzi
Aug 26, 1998·The Journal of Clinical Investigation·A J BarberT W Gardner
Oct 16, 1999·Primary Care·B A Ramlo-Halsted, S V Edelman
Nov 21, 2000·Lancet·J McKinlay, L Marceau
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alistair J Barber
Sep 1, 1961·Archives of Ophthalmology·D G COGANT KUWABARA
May 1, 1961·American Journal of Ophthalmology·J R WOLTER
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Ying HanAnthony J Adams
Jul 28, 2004·Investigative Ophthalmology & Visual Science·Ahmed M Abu-El-AsrarKarel Geboes
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Pamela M MartinSylvia B Smith
Aug 1, 1950·American Journal of Ophthalmology·J S FRIEDENWALD
Nov 4, 2004·Ophthalmology·Tony RealiniLaurie Barber
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Sahng Y KimGerard A Lutty
May 26, 2005·Investigative Ophthalmology & Visual Science·Alistair J BarberSarah K Bronson
Jun 28, 2005·Investigative Ophthalmology & Visual Science·Kristian KlempMichael Larsen
Nov 16, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Masahiko SugimotoYukitaka Uji
Dec 31, 2005·Investigative Ophthalmology & Visual Science·Matthew D ChamberlainPaul N Baird
Dec 31, 2005·Investigative Ophthalmology & Visual Science·Haidong ZouSuqin Yu
Feb 16, 2006·Archives of Ophthalmology·Annie ChanJoel S Schuman
Jun 27, 2006·Investigative Ophthalmology & Visual Science·Matthew J GastingerAlistair J Barber
Sep 5, 2006·Progress in Retinal and Eye Research·Marcus A BearseShirin Barez
Nov 24, 2006·Investigative Ophthalmology & Visual Science·Hélène KergoatMarianne Lemay
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Dennis Shun Chiu LamChristopher Kai-Shun Leung
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Jason S NgAnthony J Adams
Jun 21, 2008·The Journal of Physiology·Timothy S Kern, Alistair J Barber
Nov 11, 2008·Retina·Stela VujosevicEdoardo Midena
Aug 22, 2009·Investigative Ophthalmology & Visual Science·Sotaro OotoNagahisa Yoshimura
Feb 5, 2010·Investigative Ophthalmology & Visual Science·Hille W van DijkMichael D Abràmoff
Oct 12, 2010·Investigative Ophthalmology & Visual Science·Wendy W HarrisonAnthony J Adams
Feb 16, 2011·Archives of Ophthalmology·Thomas W GardnerGregory R Jackson
Oct 13, 2011·Investigative Ophthalmology & Visual Science·Sotaro OotoNagahisa Yoshimura
Dec 14, 2011·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Pilar A M MorenoTiago Santos Prata

❮ Previous
Next ❯

Citations

Jan 5, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Samir Helmy Assaad KhalilAlexey V Zilov
Apr 17, 2020·PloS One·Jacoba A van de KreekeFrank D Verbraak
Jul 20, 2019·Alzheimer's Research & Therapy·Jurre den HaanKeir X X Yong
May 23, 2020·Clinical Ophthalmology·Amir Tengku-FatishahIsmail Shatriah
Sep 22, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Nicole KarsonWendy W Harrison
Oct 9, 2020·The British Journal of Ophthalmology·JenniMaria HuruM Johanna Liinamaa
Dec 2, 2020·Acta Ophthalmologica·Eline E B De ClerckCarroll A B Webers
Jun 22, 2021·Journal of Diabetes Research·Shani PillarAndrzej Grzybowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Fatih C GundoganSami Toyran
Investigative Ophthalmology & Visual Science
Hille W van DijkMichael D Abramoff
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
João Paulo CunhaAntónio Castanheira-Dinis
© 2022 Meta ULC. All rights reserved