MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease)

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Allister J GrantD H Adams

Abstract

Mucosal addressin cell adhesion molecule (MAdCAM-1) plays a pivotal role in T-lymphocyte homing to the gut. Given the strong association between the autoimmune liver diseases primary sclerosing cholangitis and autoimmune hepatitis and inflammatory bowel disease, we investigated the role of MAdCAM-1 in recruiting mucosal lymphocytes to the liver. MAdCAM-1 was strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune mediated liver disease. In modified Stamper-Woodruff assays, MAdCAM-1 on hepatic vessels supported adhesion of alpha4beta7+ lymphocytes (i.e., gut-derived T cells) from patients with inflammatory bowel disease and primary sclerosing cholangitis. This adhesion was inhibited by pretreatment with blocking antibodies to MAdCAM-1, alpha4beta7, or the integrin alpha4 chain indicating that MAdCAM-1 in inflamed liver is functionally active. Circulating lymphocytes from patients with primary sclerosing cholangitis showed rolling adhesion on MAdCAM-1 transfectants in a flow-based adhesion assay that could be blocked by anti-MAdCAM-1 or anti-alpha4beta7 mAbs. These findings indicate that, under certain circumstances, vessels in the human liver support adhesion of alpha4beta7+ mucosal lymphocytes via bindin...Continue Reading

Citations

Apr 9, 2008·Inflammatory Bowel Diseases·Bertus EksteenDavid H Adams
Apr 23, 2011·Journal of Neural Transmission·Chris J Weston, David H Adams
Jul 16, 2008·Clinical Reviews in Allergy & Immunology·Birgit Terjung, Ulrich Spengler
Dec 21, 2010·Clinical Reviews in Allergy & Immunology·Christopher L Bowlus
Jul 31, 2013·Journal of Autoimmunity·Palak J Trivedi, David H Adams
Jul 3, 2013·Lancet·Gideon M HirschfieldDavid H Adams
Jun 10, 2011·Best Practice & Research. Clinical Gastroenterology·C Y Ponsioen
Feb 25, 2006·Nature Reviews. Immunology·David H Adams, Bertus Eksteen
Feb 25, 2006·Nature Reviews. Immunology·Francesca Aloisi, Ricardo Pujol-Borrell
Aug 26, 2006·Nature Reviews. Immunology·William W Agace
Mar 1, 2002·Immunology and Cell Biology·Patricia F LalorDavid H Adams
Jan 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·David H AdamsHartmut Jaeschke
Jan 10, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sumera KarimPatricia F Lalor
Oct 13, 2006·Current Opinion in Gastroenterology·Jayant A Talwalkar, Keith D Lindor
Mar 18, 2008·Journal of Clinical Gastroenterology·Daan W HommesSander J van Deventer
Jul 31, 2004·Immunology and Cell Biology·Euphemia LeungGeoffrey W Krissansen
Jan 14, 2003·Gut·A H Lau, A W Thomson
May 13, 2010·Digestive Diseases·Ye H OoDavid H Adams
Jun 9, 2012·Case Reports in Gastroenterology·Masaki ShimizuAkihiro Yachie
Jul 9, 2011·PLoS Pathogens·Elena MartinelliMelissa Robbiani
Jun 6, 2008·World Journal of Gastroenterology : WJG·Roger Chapman, Sue Cullen
Jul 9, 2008·World Journal of Gastroenterology : WJG·Ali Shorbagi, Yusuf Bayraktar
Jan 10, 2012·World Journal of Gastroenterology : WJG·Bjarte FosbyEspen Melum
Apr 24, 2013·Hepatitis Monthly·Abbas Ali Imani FooladiSeyed Moayed Alavian
Aug 2, 2014·Seminars in Immunopathology·Evaggelia LiaskouM Eric Gershwin
May 27, 2009·Seminars in Immunopathology·Jonathan H Aron, Christopher L Bowlus
Jun 18, 2009·Seminars in Immunopathology·Andrea T BorchersM Eric Gershwin
Feb 1, 2013·Expert Review of Gastroenterology & Hepatology·James H Tabibian, Keith D Lindor
Sep 1, 2006·Expert Review of Clinical Immunology·Marcus Svensson, William W Agace
Jan 27, 2016·Expert Review of Gastroenterology & Hepatology·Dino TarabarDavid T Rubin
May 8, 2014·Expert Review of Clinical Pharmacology·Svend T Rietdijk, Geert R D'Haens
Jan 30, 2016·Nature Reviews. Drug Discovery·Klaus LeySanford Shattil
Feb 14, 2016·Journal of Autoimmunity·Palak J TrivediDavid H Adams
Nov 15, 2012·Molecular Immunology·Luca G Guidotti, Matteo Iannacone
Feb 7, 2012·Clinics and Research in Hepatology and Gastroenterology·P J Trivedi, R W Chapman
Feb 23, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Tom H KarlsenKirsten M Boberg
Sep 12, 2009·Journal of Autoimmunity·Ye H Oo, David H Adams
Feb 13, 2015·Intractable & Rare Diseases Research·Ahmad H AliKeith D Lindor
Sep 9, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alina SchrederChristian Koenecke
Jul 28, 2015·Cellular and Molecular Gastroenterology and Hepatology·Sara OmenettiTheresa T Pizarro

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