Mar 31, 2010

Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents

Antimicrobial Agents and Chemotherapy
Wendy W J van de SandeAlex van Belkum

Abstract

Eumycetoma caused by Madurella mycetomatis is treated surgically and with high doses of ketoconazole. Therapeutic responses are poor, and recurrent infections are common. In search of therapeutic alternatives in the treatment of mycetoma, we determined the in vitro susceptibilities of M. mycetomatis isolates against caspofungin, anidulafungin, and micafungin. As a comparator fungus, Aspergillus fumigatus was used. Minimal effective concentrations (MECs) and MICs were assessed and compared to those of ketoconazole. M. mycetomatis isolates were not susceptible to the echinocandins.

  • References11
  • Citations18

Citations

Mentioned in this Paper

Antibiotics, Antifungal
Anidulafungin
Aspergillus fumigatus extract
Etiology
Madurella mycetomatis
Caspofungin
Mulundocandins
Aspergillus fumigatus
Micafungin
Fungi

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