Maekmoondong-tang in treatment of postoperative cough in patients with lung cancer: Study protocol for a randomized, double-blind, placebo-controlled, multicenter trial

Medicine
Chunhoo CheonSeong-Gyu Ko

Abstract

Cough is a common symptom that occurs in 25% of patients after lung cancer surgery. It might last a long time and degrade the quality of life of patients. Maekmoondong-tang (Bakumondo-to in Japanese or Mai-Men-Dong-Tang in Chinese) is a herbal medicine which has been widely used for respiratory diseases with cough in Korea, China, and Japan. The aim of the present study is to evaluate the efficacy and safety of Maekmoondong-tang for postoperative cough in patient with lung cancer. This study is a randomized, double-blind, placebo-controlled, multicenter trial of Maekmoondong-tang. A total of 96 participants will be enrolled and allocated to 2 parallel groups: the Maekmoondong-tang group and the placebo group from 5 university hospitals. The participants will be administered either Maekmoondong-tang or a placebo 3 times a day for 4 weeks. The primary outcome measurement is the change in the Leicester Cough Questionnaire (LCQ) score. The secondary outcome measurements are the changes in the cough visual analog scale and Yin Deficiency Scale. The participants will visit 4 times in total for 4 weeks of trial period. The present study will be the first multicener study to evaluate the efficacy and safety of Maekmoondong-tang for pos...Continue Reading

References

Dec 28, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·H AizawaN Hara
Dec 29, 2004·The Annals of Thoracic Surgery·Noriyoshi SawabataHikaru Matsuda
Feb 8, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ching Hsaing HsuTung Ti Chang
Dec 24, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kenichi MukaidaNobuoki Kohno
Sep 7, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Young-Jae ParkYoung-Bae Park
Mar 10, 2015·Allergy, Asthma & Immunology Research·Jae Woo KwonUNKNOWN Work Group for Chronic Cough, the Korean Academy of Asthma, Allergy and Clinical Immunology
Dec 17, 2015·Journal of Ethnopharmacology·Kwan-Il KimHyangsook Lee

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