MAFB mediates the therapeutic effect of sleeve gastrectomy for obese diabetes mellitus by activation of FXR expression

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Jian XuJingang Liu

Abstract

Farnesoid X receptor (FXR) and related pathways are involved in the therapeutic effect of sleeve gastrectomy for overweight or obese patients with diabetes mellitus. This study aimed to investigate the mechanism of FXR expression regulation during the surgical treatment of obese diabetes mellitus by sleeve gastrectomy. Diabetic rats were established by combined streptozotocin and high-fat diet induction. Data collection included body weight, chemical indexes of glucose and lipid metabolism, liver function, and the expression levels of musculoaponeurotic fibrosarcoma oncogene family B (MAFB), FXR, and related genes induced by sleeve gastrectomy. Chang liver cells overexpressing MAFB gene were established to confirm the expression of related genes. The binding and activation of FXR gene by MAFB were tested by Chip and luciferase reporter gene assays. Vertical sleeve gastrectomy induced significant weight loss and decreased blood glucose and lipids in diabetic rat livers, as well as decreased lipid deposition and recovered lipid function. The expression of MAFB, FXR, and FXR-regulated genes in diabetic rat livers were also restored by sleeve gastrectomy. Overexpression of MAFB in Chang liver cells led to FXR gene expression activa...Continue Reading

References

Feb 19, 2002·Kidney International·Thorsten P DegenhardtJohn W Baynes
Nov 27, 2004·Endocrinology·Keith R StayrookThomas P Burris
Mar 22, 2005·The Biochemical Journal·Brian L KnightGeoffrey F Gibbons
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yanqiao ZhangPeter A Edwards
Jul 11, 2006·The Journal of Clinical Investigation·Marc Prentki, Christopher J Nolan
Oct 16, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Richdeep S GillShahzeer Karmali
May 21, 2011·The Journal of Biological Chemistry·Tabitha C TingMakoto Miyazaki
Jul 2, 2011·Trends in Endocrinology and Metabolism : TEM·Yan Hang, Roland Stein
Mar 1, 2008·Current Protocols in Pharmacology·Kenneth K Wu, Youming Huan
Jan 11, 2014·Current Cardiology Reports·Mercedes R CarnethonLatha Palaniappan
Mar 29, 2014·Nature·Karen K RyanRandy J Seeley
Apr 12, 2014·Journal of the American Society of Nephrology : JASN·Naoki MoritoSatoru Takahashi
Jul 31, 2014·Pharmacological Reviews·Tiangang Li, John Y L Chiang
Mar 10, 2015·General and Comparative Endocrinology·Yu WangShicui Zhang
Jun 6, 2015·Digestive Diseases·Steven A Kliewer, David J Mangelsdorf
Nov 11, 2015·Methods in Molecular Biology·Matthew C GageInés Pineda-Torra
Nov 12, 2015·American Journal of Physiology. Endocrinology and Metabolism·Elizabeth ConradRoland Stein
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Guodong Li, Grace L Guo
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Sharon Manley, Wenxing Ding
Jun 18, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lili DingWendong Huang
Jul 16, 2016·FEBS Open Bio·Mai Thi Nhu TranSatoru Takahashi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
transfection
immunoprecipitation
Chip

Software Mentioned

JASPAR
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Jiang-Long HongMing-Jun Bai
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Yan DingHua-Rong Li
© 2022 Meta ULC. All rights reserved