Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy.

BioRxiv : the Preprint Server for Biology
Sally Wheatley, A. R. Townley

Abstract

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which remains to be elucidated. Here, we report that mitochondrial survivin inhibits the selective form of autophagy, called mitophagy, causing an accumulation of respiratory defective mitochondria. Mechanistically the data reveal that survivin prevents recruitment of the E3-ubiquitin ligase Parkin to mitochondria and their subsequent recognition by the autophagosome. The data also demonstrate that, as a consequence of this blockade, cells expressing high levels of survivin have an increased dependency on anaerobic glycolysis. As these effects were found exclusively in cancer cells they suggest that the primary act of mitochondrial survivin is to force cells to implement the Warburg Effect by inhibiting mitochondrial turnover.

Related Concepts

Study
Nucleic Acid Sequencing
Macrophage-Activating Factors
Sequencing
Downstream
Analysis
Malignant Neoplasms
Mutation Abnormality
Cohort
Landscapes

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Cancer Genomics (Preprints)

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest preprints here.

Related Papers

BioRxiv : the Preprint Server for Biology
Zachary L SkidmoreMalachi Griffith
BioRxiv : the Preprint Server for Biology
Brian J Knaus, Niklaus J Grunwald
© 2020 Meta ULC. All rights reserved