MAG, a novel plasma protein receptor from Streptococcus dysgalactiae

Gene
H JonssonB Guss

Abstract

The gene encoding a plasma protein receptor from Streptococcus dysgalactiae has been cloned and sequenced. The gene product, with a predicted molecular mass of approx. 44 kDa, binds alpha 2-macroglobulin (alpha 2 M), serum albumin and immunoglobulin G (IgG). By subcloning and expressing various parts of the gene as fusion proteins, we found that the three binding activities reside in discrete domains of the protein. The single IgG-binding domain, localized in the C-terminal part of the molecule, shows high homology to streptococcal type-III Fc receptors. In the middle of the molecule, there is a stretch of 50 amino acids (aa) mediating albumin binding. This region has partial homology with the albumin-binding domains of streptococcal protein G. The alpha 2 M-binding domain is located in the N terminus of the molecule and is composed of a unique aa sequence. We call this trifunctional plasma protein receptor, MAG (binds alpha 2 M, albumin and IgG).

References

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Citations

Dec 1, 2005·Applied Microbiology and Biotechnology·Emily M CoyleMichael D P Boyle
May 18, 1995·Biochimica Et Biophysica Acta·H JonssonB Guss
Jan 9, 2004·Protein Expression and Purification·Jose Perez-CasalAndrew A Potter
Jul 1, 1998·Veterinary Microbiology·L F CalvinhoS P Oliver
Dec 22, 1999·Infection and Immunity·J VasiB Guss
Sep 2, 2009·Microbiology and Molecular Biology Reviews : MMBR·Angela H NobbsHoward F Jenkinson
May 17, 2011·Biochemistry. Biokhimii︠a︡·E V Sidorin, T F Solov'eva
Jul 1, 1997·Microbiological Research·K JacobssonL Frykberg
Mar 14, 1997·Journal of Molecular Biology·M U JohanssonL Björck
Oct 25, 1996·The Journal of Biological Chemistry·M de ChâteauL Björck
Dec 7, 2018·Journal of Chromatography. a·Raquel Dos SantosA Cecília A Roque
Mar 6, 1999·Microbiology and Molecular Biology Reviews : MMBR·W W Navarre, O Schneewind
Mar 16, 2019·Microbiology Spectrum·Horst Malke
May 22, 2019·Microbiology Spectrum·Claire E TurnerAndroulla Efstratiou
Aug 1, 1995·Infection and Immunity·H P Müller, L K Rantamäki
Aug 1, 1995·Infection and Immunity·H JonssonB Guss
Aug 8, 2021·Microorganisms·Tina KabelitzMarcus Fulde

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