MAGE-A antigens as targets for cancer immunotherapy

Cancer Treatment Reviews
Erik SchootenMarta M Kijanka

Abstract

Targeted anti-cancer therapies aim at reducing side effects while retaining their anti-cancer efficacy. Immunotherapies e.g. monoclonal antibodies, adoptive T cell therapy and cancer vaccines are used to combat cancer, but the number of available cancer specific targets is limited and new approaches are needed to generate more effective and patient tailored treatments. Unique cancer intracellular epitopes can be presented on the cell surface by MHC class I molecules, which can function as epitopes for targeted therapies. The intracellular MAGE proteins belong to a sub-class of Cancer Testis (CT) antigens which are expressed in germline cells and a wide variety of tumors of different histological origin. Evidence has emerged that their expression is linked to pro-tumorigenic activities like increased cell motility, resisting cell death, and tumor promoting inflammation. Intracellular MAGE proteins are processed by the proteasome and their peptides are presented by MHC class I molecules on the cell surface of cancer cells thereby making them ideal cancer specific antigens. Here we review the previous and ongoing (pre-) clinical studies on the use of surface expressed MAGE antigens for their employment in targeted anti-cancer ther...Continue Reading

Citations

Apr 25, 2019·International Journal of Molecular Sciences·Eishiro Mizukoshi, Shuichi Kaneko
Jan 19, 2019·Journal of Cancer Research and Clinical Oncology·Yujie ZhangLi Zhang
Aug 29, 2019·Frontiers in Oncology·Alexey V Morozov, Vadim L Karpov
Mar 13, 2020·Cancer Management and Research·Shiheng JiaWei Dai
Jul 6, 2019·Advanced Drug Delivery Reviews·Naama MargolisGal Markel
Oct 13, 2019·Seminars in Immunology·Jean-Philippe BastienDenis Claude Roy
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liza O'DonnellPeter G Stanton
Mar 21, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Azadeh KhalvandiMonireh Mohsenzadegan
May 20, 2021·Journal of Experimental & Clinical Cancer Research : CR·Xiang-Yuan LuoXing-Xing He
Jul 19, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Yuanyang WangWeibin Wang
Oct 13, 2021·Nature Biotechnology·Chloe ChongMichal Bassani-Sternberg
Sep 2, 2021·Molecular Cancer Therapeutics·Yajing ZhangYi Li

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