Maggot debridement therapy promotes diabetic foot wound healing by up-regulating endothelial cell activity

Journal of Diabetes and Its Complications
Xinjuan SunAiping Wang

Abstract

To determine the role of maggot debridement therapy (MDT) on diabetic foot wound healing, we compared growth related factors in wounds before and after treatment. Furthermore, we utilized human umbilical vein endothelial cells (HUVECs) to explore responses to maggot excretions/secretions on markers of angiogenesis and proliferation. The results showed that there was neo-granulation and angiogenesis in diabetic foot wounds after MDT. Moreover, significant elevation in CD34 and CD68 levels was also observed in treated wounds. In vitro, ES increased HUVEC proliferation, improved tube formation, and increased expression of vascular endothelial growth factor receptor 2 in a dose dependent manner. These results demonstrate that MDT and maggot ES can promote diabetic foot wound healing by up-regulating endothelial cell activity.

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Citations

Apr 5, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Adrienne L BrundageJeffery K Tomberlin
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Litao YanShouyu Wang
Jun 29, 2018·EFORT Open Reviews·Önder I KılıçoğluŞamil Aktaş
Nov 5, 2019·International Wound Journal·Olga von BeckerathBenjamin Juntermanns
Sep 18, 2020·Advances in Skin & Wound Care·José Moya-LópezElvira De Luna-Bertos
Oct 28, 2019·Antibiotics·Jesus Manuel Ramirez-AcuñaMargarita L Martinez-Fierro
Nov 7, 2019·Journal of Clinical Medicine·Dariusz BazalińskiPaweł Więch
Sep 29, 2020·Journal of Biomedical Materials Research. Part a·Shirin NourAli Mohammad Sharifi

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