Magnesium and inflammation: Advances and perspectives.

Seminars in Cell & Developmental Biology
Jeanette A M MaierAndré Mazur

Abstract

Magnesium is an essential element of life, involved in the regulation of metabolism and homeostasis of all the tissues. It also regulates immunological functions, acting on the cells of innate and adaptive immune systems. Magnesium deficiency primes phagocytes, enhances granulocyte oxidative burst, activates endothelial cells and increases the levels of cytokines, thus promoting inflammation. Consequently, a low magnesium status, which is often underdiagnosed, potentiates the reactivity to various immune challenges and is implicated in the pathophysiology of many common chronic diseases. Here we summarize recent advances supporting the link between magnesium deficiency, inflammatory responses and diseases, and offer new hints towards a better understanding of the underlying mechanisms.

References

Dec 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C B Cairns, M Kraft
Jan 14, 1999·British Journal of Pharmacology·M MalcangioD R Tomlinson
Dec 11, 2002·British Journal of Haematology·Joen-Rong SheuDuen-Suey Chou
Jul 31, 2003·Cell·Carsten SchmitzAndrew M Scharenberg
Mar 17, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Daniela BernardiniJeanette A M Maier
Mar 30, 2006·Neurobiology of Aging·Antón AlvarezManuel Aleixandre
May 23, 2006·Archives of Biochemistry and Biophysics·Andrzej MazurYves Rayssiguier
May 4, 2007·Current Opinion in Pharmacology·Mike BerryAj Wardlaw
May 5, 2007·European Journal of Nutrition·Dorit Almoznino-SarafianNatan Cohen
Jul 20, 2007·The Cochrane Database of Systematic Reviews·B H RoweG W Bota
Dec 18, 2007·Cell·David E Clapham
Apr 25, 2009·Immunology and Allergy Clinics of North America·Robert Dantzer
Jan 22, 2010·The Journal of Nutrition·Barbara D PachikianNathalie M Delzenne
May 21, 2010·Arquivos brasileiros de endocrinologia e metabologia·Paulo Gustavo Sampaio Lacativa, Maria Lucia Fleiuss de Farias
Aug 19, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alaa AmashMahmoud Huleihel
Nov 4, 2010·Nature Communications·Lillia V RyazanovaAlexey G Ryazanov
Mar 17, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Junji TakayaKazunari Kaneko
May 3, 2011·Current Opinion in Rheumatology·Julie C Baker-LePainNancy E Lane
Jun 7, 2011·Archives of Biochemistry and Biophysics·Andrea M P Romani
Jul 13, 2013·Science·Benjamin Chaigne-DelalandeMichael J Lenardo
Apr 23, 2014·Magnesium Research : Official Organ of the International Society for the Development of Research on Magnesium·Carsten SchmitzAnne-Laure Perraud
Apr 29, 2014·Molecular Cell·Raj Chovatiya, Ruslan Medzhitov
Jun 19, 2014·European Journal of Clinical Nutrition·S Mahabir
Jul 6, 2014·International Journal of Molecular Sciences·Linjie HuangShanping Jiang
Sep 11, 2014·Journal of Cell Science·Tom SchillingClaudia Eder
Sep 24, 2014·Magnesium Research : Official Organ of the International Society for the Development of Research on Magnesium·Sara CastiglioniJeanette A M Maier
Dec 30, 2014·Physiological Reviews·Jeroen H F de BaaijRené J M Bindels
Feb 19, 2015·Acta Neuropsychiatrica·Gudrun WintherGregers Wegener
Mar 17, 2015·Acta Neuropsychiatrica·Bettina Pyndt JørgensenDorte B Sørensen
Mar 31, 2015·The British Journal of Nutrition·Sovianne ter BorgLisette C P G M de Groot
Nov 14, 2015·Journal of Clinical Medicine Research·Dimitrios VelissarisMenelaos Karanikolas
Nov 1, 2016·Journal of Neurochemistry·Damon J DiSabatoJonathan P Godbout

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
W P Leary, A J Reyes
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
T Bøhmer
International Journal of Molecular Sciences
Azzurra SargentiStefano Iotti
Magnesium Research : Official Organ of the International Society for the Development of Research on Magnesium
J IshizukaJ C Thompson
© 2021 Meta ULC. All rights reserved