Magnesium as an intrinsic component of human otoconia

Acta Oto-laryngologica
Leif Erik WaltherRüdiger Kniep

Abstract

To investigate morphology changes of artificial otoconia (CGC) in the presence of magnesium during growth under in vitro conditions. Investigating human otoconia by environmental scanning electron microscope and determining their magnesium content by energy-dispersive X-ray microanalysis (EDX). Comparing structural and morphological data of human and artificial otoconia (CGC, Ca1Mg0) without and with magnesium substitution (Ca1-xMgx). EDX- and X-ray data reveals that the inorganic component in human otoconia consists of calcite containing a minor amount of magnesium substitution (Ca1-xMgx). CGC containing magnesium (length 397.0 ± 146.4 µm, diameter 325.6 ± 100.1 µm) are slimmer and significantly smaller (p < .01) than pure CGC (length 548.6 ± 160 µm, diameter 373.0 ± 110.4 µm) and reveal a significant influence on the final morphology. The length/diameter ratio is significantly higher by incorporation of magnesium into CGC (1.84 ± 0.25 µm versus 1.48 ± 0.11 µm in pure CGC, p < .01), which brings the overall shape to a close relationship with human otoconia (1.98 ± 0.08 µm). Magnesium is an intrinsic component of human otoconia by partial substitution of calcium in the calcite crystal structure (Ca1-xMgx) and affects the develo...Continue Reading

References

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Nov 13, 2013·Acta Oto-laryngologica·Leif Erik WaltherRüdiger Kniep
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Jul 23, 2014·PloS One·Leif Erik WaltherRüdiger Kniep
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