Magnesium attenuates a striatal dopamine increase induced by anoxia in the neonatal rat brain: an in vivo microdialysis study

Pediatric Research
W NakajimaG Takada

Abstract

We evaluated the effects of magnesium on extracellular dopamine (DA) and its metabolites in the striatum of 5-d-old rats submitted to 16 min of anoxia using microdialysis and HPLC. Rat pups were divided into three groups and received either 1) intrastriatal perfusion (IS) of MgSO4, 2) intraperitoneal injection (IP) of MgSO4, and 3) NaCl and Ringer's solution, respectively in place of MgSO4. After stabilization, Mg2+, saline, and Ringer's solution were administered; then, 114 animals were exposed to 100% nitrogen for 16 min. Anoxia induced a DA surge, an acutely marked increase of DA, in both the control and the IP group. In contrast, the DA surge was significantly suppressed in the IS group (p < 0.01, analysis of variance). During anoxia, the plasma Mg2+ in the IP group, but not in the IS group, maintained a significantly higher level compared with the basal level. On the other hand, Mg2+ in the perfusates in the IS group, but not in the IP group, maintained a significantly high level during anoxia. Alterations induced by anoxia in other metabolites, 3,4-dihydroxyphenylacetic acid, homovanillic acid, norepinephrine, and 5-hydroxyindole-3-acetic acid, did not significantly differ among the three groups. We propose that elevated ...Continue Reading

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Citations

Mar 10, 2001·Mental Retardation and Developmental Disabilities Research Reviews·J J Volpe
Jun 16, 2001·Indian Journal of Pediatrics·G Gathwala
Mar 29, 2006·Indian Journal of Pediatrics·Geeta GathwalaIshwar Singh
Sep 13, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroyuki IchibaUNKNOWN Kansai Magnesium Study Group
May 12, 2011·Journal of Pediatric Neurosciences·Geeta GathwalaBharti Balhara
May 24, 2017·Frontiers in Cellular Neuroscience·Lancelot J MillarZoltán Molnár

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