PMID: 8959161Dec 1, 1996Paper

Magnesium attenuates the neutrophil respiratory burst in adult asthmatic patients

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
C B Cairns, M Kraft

Abstract

IV magnesium (Mg2+) has been proposed as an emergent treatment for acute asthma exacerbations. Recent studies have focused on the effects of Mg2+ on bronchial smooth muscle, yet asthma is primarily an inflammatory disease. To assess the effects of Mg2+ on the neutrophil respiratory burst of adult patients with asthma. A prospective, blind study of volunteer adult asthmatic patients was performed. The patients' polymorphonuclear neutrophils (PMNs) were isolated, purified, and placed into phosphate-buffered saline with the following test conditions: concentrations of magnesium chloride (MgCl2) added: 0 mmol MgCl2, 1 mmol MgCl2 (low), and 10 mmol MgCl2 (high) both with and without the calcium (Ca2+) ionophore A23187 (0.1 mmol). PMNs were activated using N-formyl-methionyl-leucyl-phenylalanine (fMLP) (10 mumol), and the production of superoxide (O2-) was measured by the spectrophotometric reduction of cytochrome c. Mg2+ reduced activated PMN O2- production compared with that for no Mg2+ (1.0 +/- 0.1 nmol O2-/5 x 10(5) PMN/min) in both low (-0.52* +/- 0.3 nmol O2-/5 x 10(5) PMN/min) and high (-0.76* +/- 0.3 nmol O2-/5 x 10(5) PMN/min; *p < 0.05) concentrations. The addition of A23187 increased O2- production in both the high (0.53* ...Continue Reading

References

Jul 15, 1992·Biochemical and Biophysical Research Communications·K AoyagiS Minakami
Sep 1, 1992·Annals of Emergency Medicine·V T Chande, D P Skoner
Oct 1, 1990·Annals of Emergency Medicine·W H SpiveyR M Levin
Dec 1, 1989·The American Review of Respiratory Disease·A M SustielL Borish
Sep 1, 1989·JAMA : the Journal of the American Medical Association·E M SkobeloffL Greenspon
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Feb 27, 1987·JAMA : the Journal of the American Medical Association·H OkayamaT Takishima
Jul 31, 1984·Biochemical and Biophysical Research Communications·J M RobinsonM J Karnovsky
Aug 30, 1983·Biochemical and Biophysical Research Communications·T YamaguchiK Kakinuma
Jul 1, 1984·American Heart Journal·L T Iseri, J H French
May 1, 1994·Mayo Clinic Proceedings·S SurG J Gleich
Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S K SharmaJ N Pande
Jan 1, 1994·The American Journal of Medicine·R M McLean
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M KraftR J Martin

❮ Previous
Next ❯

Citations

Nov 23, 2013·Current Opinion in Pulmonary Medicine·Colin V E Powell
Nov 29, 2007·Current Opinion in Pulmonary Medicine·Brian H Rowe, Carlos A Camargo
Dec 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·E M Skobeloff
Dec 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·R K Cydulka
Nov 26, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Thomas KovesiR Andrew McIvor
Jul 22, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Fedoua GandiaZouhair Tabka
Nov 17, 2009·Drugs·Spyros A PapirisIraklis Tsangaris
Jan 17, 2014·The Lancet. Respiratory Medicine·Colin PowellUNKNOWN MAGNETIC study group
Jan 17, 2014·The Lancet. Respiratory Medicine·Brian H Rowe
Jul 9, 2005·Chest·Maurice BlitzBrian H Rowe
Aug 13, 2002·Chest·Robert A SilvermanUNKNOWN Acute Asthma/Magnesium Study Group
Apr 11, 2012·Emergency Medicine Clinics of North America·Ariana Murata, Patrick M Ling
Apr 27, 2010·Pulmonary Pharmacology & Therapeutics·M C Gallegos-SolórzanoRafael J Hernández-Zenteno
Apr 21, 2009·La Revue de médecine interne·A ForestM Verny
Jan 13, 2009·Pediatric Clinics of North America·Paul D Robinson, Peter Van Asperen
Mar 18, 2006·Clinics in Chest Medicine·Charles B Cairns
Jan 22, 2011·Journal of Biomedical Materials Research. Part a·Felicity C EdwardsJulian F Dye
Jul 25, 2000·Clinics in Chest Medicine·R Silverman
Dec 19, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Waleed H Albuali
Sep 18, 2007·Respiratory Medicine·Tracey A BradshawAndrew P Greening
Jan 25, 2005·Journal of Intensive Care Medicine·Garrison M Tong, Robert K Rude
May 3, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Fogarty, J Britton
Apr 30, 2016·The Cochrane Database of Systematic Reviews·Benedict Griffiths, Kayleigh M Kew
May 5, 2000·The Cochrane Database of Systematic Reviews·B H RoweC A Camargo
Mar 3, 2011·Anesthesiology·Susanne HerroederMarkus W Hollmann
Jan 14, 2009·Journal of Clinical Laboratory Analysis·Slavica DodigBoro Nogalo
Nov 4, 2005·Journal of the American Veterinary Medical Association·Edward S CooperW Tod Drost
Feb 16, 2006·Biology of the Neonate·Rajeev Mehta, Anna Petrova
Dec 2, 2005·Scandinavian Journal of Clinical and Laboratory Investigation·R SinertB M Altura
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Richard Beasley, Sarah Aldington
Oct 20, 1998·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M HarariJ Shani
Jun 7, 2019·Inflammopharmacology·Abbas ShahiMahdi Mahmoudi
Nov 4, 2000·Clinical and Diagnostic Laboratory Immunology·N ReinischG Ricevuti
Jul 11, 2020·Journal of the American College of Nutrition·Taylor C Wallace
May 28, 2020·Expert Opinion on Pharmacotherapy·Alessandro VatrellaCarolina Vitale
Jun 24, 2020·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·John Conway, Benjamin Friedman
Sep 12, 2020·Advanced Materials·Saber Amin YavariMichiel Croes
Nov 29, 2017·The Cochrane Database of Systematic Reviews·Rachel KnightlyColin Powell
May 1, 2018·American Journal of Reproductive Immunology : AJRI·Sarah N CrossVikki M Abrahams
Jun 1, 2018·International Journal of Endocrinology·Abdullah M Al AlawiHenrik Falhammar
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Colin PowellBrian H Rowe
Sep 7, 2016·Allergologia et immunopathologia·I Maloča VuljankoD Plavec
Feb 9, 2021·Frontiers in Immunology·Geoffrey P DobsonJodie L Morris
Apr 9, 2021·Pediatric Pulmonology·Milton Gross JúniorPaulo Roberto Antonacci Carvalho
Nov 23, 2020·Seminars in Cell & Developmental Biology·Jeanette A MaierAndré Mazur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
K I GourgoulianisP A Molyvdas
The Journal of Allergy and Clinical Immunology
B H RoweMulticenter Airway Research Collaboration (MARC) Investigators
© 2021 Meta ULC. All rights reserved